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dc.contributor.authorNguyen, Duc-Huy T.en_US
dc.contributor.authorLee, Esaken_US
dc.contributor.authorAlimperti, Stylianien_US
dc.contributor.authorNorgard, Robert J.en_US
dc.contributor.authorWong, Alecen_US
dc.contributor.authorLee, Jake June-Kooen_US
dc.contributor.authorEyckmans, Jeroenen_US
dc.contributor.authorStanger, Ben Z.en_US
dc.contributor.authorChen, Christopher S.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2019-07-25
dc.date.accessioned2020-04-14T15:49:55Z
dc.date.available2020-04-14T15:49:55Z
dc.date.issued2019-08
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31489365
dc.identifier.citationDuc-Huy T Nguyen, Esak Lee, Styliani Alimperti, Robert J Norgard, Alec Wong, Jake June-Koo Lee, Jeroen Eyckmans, Ben Z Stanger, Christopher S Chen. 2019. "A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling.." Sci Adv, Volume 5, Issue 8, pp. eaav6789. https://doi.org/10.1126/sciadv.aav6789
dc.identifier.issn2375-2548
dc.identifier.urihttps://hdl.handle.net/2144/40146
dc.description.abstractPancreatic ductal adenocarcinoma (PDAC) is an aggressive, lethal malignancy that invades adjacent vasculatures and spreads to distant sites before clinical detection. Although invasion into the peripancreatic vasculature is one of the hallmarks of PDAC, paradoxically, PDAC tumors also exhibit hypovascularity. How PDAC tumors become hypovascular is poorly understood. We describe an organotypic PDAC-on-a-chip culture model that emulates vascular invasion and tumor-blood vessel interactions to better understand PDAC-vascular interactions. The model features a 3D matrix containing juxtaposed PDAC and perfusable endothelial lumens. PDAC cells invaded through intervening matrix, into vessel lumen, and ablated the endothelial cells, leaving behind tumor-filled luminal structures. Endothelial ablation was also observed in in vivo PDAC models. We also identified the activin-ALK7 pathway as a mediator of endothelial ablation by PDAC. This tumor-on-a-chip model provides an important in vitro platform for investigating the process of PDAC-driven endothelial ablation and may provide a mechanism for tumor hypovascularity.en_US
dc.description.sponsorshipR01 EB000262 - NIBIB NIH HHS; TL1 TR001410 - NCATS NIH HHS; UC4 DK104196 - NIDDK NIH HHS; UH3 EB017103 - NIBIB NIH HHSen_US
dc.format.extentp. eaav6789en_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofSci Adv
dc.rightsCopyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleA biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signalingen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1126/sciadv.aav6789
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0003-1475-8149 (Eyckmans, Jeroen)
dc.identifier.orcid0000-0003-2445-8449 (Chen, Christopher S)
dc.identifier.mycv487930


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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Except where otherwise noted, this item's license is described as Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).