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dc.contributor.authorLertpitayakun, Prindaen_US
dc.date.accessioned2020-04-14T18:20:02Z
dc.date.available2020-04-14T18:20:02Z
dc.date.issued1997
dc.date.submitted1997
dc.identifier.other(OCoLC)39191670
dc.identifier.otherb22012692
dc.identifier.urihttps://hdl.handle.net/2144/40152
dc.descriptionThesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 1997 (Pediatric Dentistry).en_US
dc.descriptionIncludes bibliographical references (leaves 91-103).en_US
dc.description.abstractRecent concerns have been raised about estrogenic chemicals, mainly bisphenol-A (BPA), being leached out of dental seaIants. The aim of this in vitro study was to identify and quantify BPA and other components released from seven light cured fissure sealants (Delton, Dentsply; Concise, 3M; Helioseal, Vivadent; Prisma:Shield, Dentsply; Seal-Rite l & l, Pulpdent; Defender, Henry Schein). Fifty microIiters of each seaIant was placed in a gIass dappen dish and cured for 50 seconds. After curing, the sample was removed from the dappen dish, weighed and transferred to a test tube. Each sealant sample was extracted with 95% ethanol for 4 minutes, the samples were removed from the ethanol and the extracts were analyzed by high performance liquid chromatography (HPLC). Standard solutions containing BPA, triethyleneglycol dimethacrylate (TEGDMA), bis-glycidyl dimethacrylate (Bis-GMA), urethane dimethacrylate (UDMA) and bisphenol-A dimethacrylate (Bis-DMA) were analyzed by HPLC under the same conditions. All chromatograms of the extracts were compared to the standards for identification of the components in each sample. One of the tested sealants, Delton was selected for further analysis by gas chromatography/mass spectroscopy (GC/MS). Results showed that BPA was not released from any of the sealants tested. Delton and Concise leached significantly more TEGDMA than Helioseal, Prisma:shield and Defender (ANOVA, P[less than]0.05). Prisma:shield, Seal-Rite I and Defender had significantly lower Bis-GMA leachability than Helioseal, Concise and Delton (ANOVA, P[less than]0.05). Only Seal-Rite II eluted UDMA. Two sealants eluted Bis-DMA (Delton, Defender). At present, since the concern about BPA leaching out of dental sealants is unwarranted, it is believed that there is no need to change or restrict the use of dental seaIants in children or adult patients. However, further studies may be required to assess the biologic effects of the other leached components that were detected.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is being made available in OpenBU by permission of its author, and is available for research purposes only. All rights are reserved to the author.en_US
dc.subjectPit and fissure sealantsen_US
dc.titleIn vitro elution of leachable components from dental sealantsen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Science in Dentistryen_US
etd.degree.levelmastersen_US
etd.degree.disciplineBiomaterialsen_US
etd.degree.grantorBoston Universityen_US


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