Show simple item record

dc.contributor.authorIvankin, Andreyen_US
dc.contributor.authorHenley, Robert Y.en_US
dc.contributor.authorLarkin, Josephen_US
dc.contributor.authorCarson, Spenceren_US
dc.contributor.authorToscano, Michael L.en_US
dc.contributor.authorWanunu, Menien_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2020-04-29T14:32:43Z
dc.date.available2020-04-29T14:32:43Z
dc.date.issued2014-10-28
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/25232895
dc.identifier.citationAndrey Ivankin, Robert Y Henley, Joseph Larkin, Spencer Carson, Michael L Toscano, Meni Wanunu. 2014. "Label-free optical detection of biomolecular translocation through nanopore arrays.." ACS Nano, Volume 8, Issue 10, pp. 10774 - 10781. https://doi.org/10.1021/nn504551d
dc.identifier.issn1936-086X
dc.identifier.urihttps://hdl.handle.net/2144/40447
dc.description.abstractIn recent years, nanopores have emerged as exceptionally promising single-molecule sensors due to their ability to detect biomolecules at subfemtomole levels in a label-free manner. Development of a high-throughput nanopore-based biosensor requires multiplexing of nanopore measurements. Electrical detection, however, poses a challenge, as each nanopore circuit must be electrically independent, which requires complex nanofluidics and embedded electrodes. Here, we present an optical method for simultaneous measurements of the ionic current across an array of solid-state nanopores, requiring no additional fabrication steps. Proof-of-principle experiments are conducted that show simultaneous optical detection and characterization of ssDNA and dsDNA using an array of pores. Through a comparison with electrical measurements, we show that optical measurements are capable of accessing equivalent transmembrane current information.en_US
dc.description.sponsorshipR01 HG006321 - NHGRI NIH HHS; R21 HG006873 - NHGRI NIH HHS; R01-HG006321 - NHGRI NIH HHS; R21-HG006873 - NHGRI NIH HHSen_US
dc.format.extentp. 10774 - 10781en_US
dc.languageeng
dc.relation.ispartofACS Nano
dc.rights"Copyright © 2014 American Chemical Society. This article appears in OpenBU by publisher permission."en_US
dc.rights.urihttps://pubs.acs.org/page/policy/authorchoice_termsofuse.html
dc.subjectFluorescenceen_US
dc.subjectIonophoreen_US
dc.subjectOptical patch-clampingen_US
dc.subjectSingle-moleculeen_US
dc.subjectBiological transporten_US
dc.subjectMicroscopy, electron, transmissionen_US
dc.subjectNanoporesen_US
dc.subjectOptics and photonicsen_US
dc.subjectMicroscopy, electron, transmissionen_US
dc.subjectBiological transporten_US
dc.subjectNanoscience & nanotechnologyen_US
dc.titleLabel-free optical detection of biomolecular translocation through nanopore arraysen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1021/nn504551d
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Physicsen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv504798


This item appears in the following Collection(s)

Show simple item record