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dc.contributor.authorChristadore, Lisaen_US
dc.contributor.authorGrinstaff, Mark W.en_US
dc.contributor.authorSchaus, Scott E.en_US
dc.date.accessioned2020-05-01T20:31:12Z
dc.date.available2020-05-01T20:31:12Z
dc.date.issued2018-04-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000434717300228&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationLisa Christadore, Mark W Grinstaff, Scott E Schaus. 2018. "Fluorescent Dendritic Micro-Hydrogels: Synthesis, Analysis and Use in Single-Cell Detection." MOLECULES, Volume 23, Issue 4,10 pp. (10). https://doi.org/10.3390/molecules23040936
dc.identifier.issn1420-3049
dc.identifier.urihttps://hdl.handle.net/2144/40515
dc.description.abstractHydrogels are of keen interest for a wide range of medical and biotechnological applications including as 3D substrate structures for the detection of proteins, nucleic acids, and cells. Hydrogel parameters such as polymer wt % and crosslink density are typically altered for a specific application; now, fluorescence can be incorporated into such criteria by specific macromonomer selection. Intrinsic fluorescence was observed at λmax 445 nm from hydrogels polymerized from lysine and aldehyde- terminated poly(ethylene glycol) macromonomers upon excitation with visible light. The hydrogel’s photochemical properties are consistent with formation of a nitrone functionality. Printed hydrogels of 150 μm were used to detect individual cell adherence via a decreased in fluorescence. The use of such intrinsically fluorescent hydrogels as a platform for cell sorting and detection expands the current repertoire of tools available.en_US
dc.description.sponsorshipThis research was supported by Boston University. We thank Michel Wathier and Phil Allen for help with the experiments. (Boston University)en_US
dc.format.extent10 pagesen_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULES
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectPhysical sciencesen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectChemistry, multidisciplinaryen_US
dc.subjectDendrimeren_US
dc.subjectHydrogelen_US
dc.subjectScreeningen_US
dc.subjectCrosslinkingen_US
dc.subjectFluorescenceen_US
dc.subjectBiomedical applicationsen_US
dc.subjectCatalyzed oxidationsen_US
dc.subjectPamam dendrimeren_US
dc.subjectDrug-deliveryen_US
dc.subjectNucleic acidsen_US
dc.subjectWound closureen_US
dc.subjectIn-vitroen_US
dc.subjectNitronesen_US
dc.subjectAminesen_US
dc.subjectAdhesivesen_US
dc.subjectMicroscopy, confocalen_US
dc.subjectPolyethylene glycolsen_US
dc.subjectSerum albumin, bovineen_US
dc.subjectSingle-cell analysisen_US
dc.subjectSpectrometry, fluorescenceen_US
dc.subjectOrganic chemistryen_US
dc.subjectTheoretical and computational chemistryen_US
dc.subjectMedicinal and biomolecular chemistryen_US
dc.titleFluorescent dendritic micro-hydrogels: synthesis, analysis and use in single-cell detectionen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.3390/molecules23040936
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Chemistryen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-5453-3668 (Grinstaff, Mark W)
dc.identifier.mycv364246


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited