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dc.contributor.authorRaudies, Florianen_US
dc.contributor.authorHasselmo, Michael E.en_US
dc.date.accessioned2020-05-07T15:47:09Z
dc.date.available2020-05-07T15:47:09Z
dc.date.issued2015-11-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000365801600046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationFlorian Raudies, Michael E. Hasselmo. 2015. "Differences in Visual-Spatial Input May Underlie Different Compression Properties of Firing Fields for Grid Cell Modules in Medial Entorhinal Cortex." PLOS COMPUTATIONAL BIOLOGY, Volume 11, Issue 11, https://doi.org/10.1371/journal.pcbi.1004596
dc.identifier.issn1553-734X
dc.identifier.issn1553-7358
dc.identifier.urihttps://hdl.handle.net/2144/40667
dc.description.abstractFiring fields of grid cells in medial entorhinal cortex show compression or expansion after manipulations of the location of environmental barriers. This compression or expansion could be selective for individual grid cell modules with particular properties of spatial scaling. We present a model for differences in the response of modules to barrier location that arise from different mechanisms for the influence of visual features on the computation of location that drives grid cell firing patterns. These differences could arise from differences in the position of visual features within the visual field. When location was computed from the movement of visual features on the ground plane (optic flow) in the ventral visual field, this resulted in grid cell spatial firing that was not sensitive to barrier location in modules modeled with small spacing between grid cell firing fields. In contrast, when location was computed from static visual features on walls of barriers, i.e. in the more dorsal visual field, this resulted in grid cell spatial firing that compressed or expanded based on the barrier locations in modules modeled with large spacing between grid cell firing fields. This indicates that different grid cell modules might have differential properties for computing location based on visual cues, or the spatial radius of sensitivity to visual cues might differ between modules.en_US
dc.description.sponsorshipThis work was funded by: Office of Naval Research ONR MURI N00014-10-1-0936; National Science Foundation CELEST SMA-0835976; National Institutes of Mental Health Silvio O. Conte Center grant NIMH P50 094263; National Institutes of Health R01 grants MH60013 and MH61492. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. (N00014-10-1-0936 - Office of Naval Research ONR MURI; SMA-0835976 - National Science Foundation CELEST; NIMH P50 094263 - National Institutes of Mental Health Silvio O. Conte Center; MH60013 - National Institutes of Health; MH61492 - National Institutes of Health)en_US
dc.format.extent27 pages.en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherPublic Library Of Scienceen_US
dc.relation.ispartofPLOS Computational Biology
dc.rights© 2015 Raudies, Hasselmo. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectBiochemical research methodsen_US
dc.subjectMathematical & computational biologyen_US
dc.subjectBiochemistry & molecular biologyen_US
dc.subjectCortical areasen_US
dc.subjectFunctional specializationen_US
dc.subjectPath-integrationen_US
dc.subjectMST neuronsen_US
dc.subjectModelen_US
dc.subjectMapen_US
dc.subjectMotionen_US
dc.subjectThetaen_US
dc.subjectParahippocampalen_US
dc.subjectRepresentationen_US
dc.subjectAction potentialsen_US
dc.subjectAnimalsen_US
dc.subjectComputational biologyen_US
dc.subjectEntorhinal cortexen_US
dc.subjectHippocampusen_US
dc.subjectModels, neurologicalen_US
dc.subjectRatsen_US
dc.subjectSpatial navigationen_US
dc.subjectVisual cortexen_US
dc.subjectBiological sciencesen_US
dc.subjectInformation and computing sciencesen_US
dc.subjectMathematical sciencesen_US
dc.subjectBioinformaticsen_US
dc.titleDifferences in visual-spatial input may underlie different compression properties of firing fields for grid cell modules in medial entorhinal cortexen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1371/journal.pcbi.1004596
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-9925-6377 (Hasselmo, Michael E)
dc.identifier.mycv64174


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© 2015 Raudies, Hasselmo. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as © 2015 Raudies, Hasselmo. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.