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dc.contributor.authorBrandon, Mark P.en_US
dc.contributor.authorBogaard, Andrew R.en_US
dc.contributor.authorSchultheiss, Nathan W.en_US
dc.contributor.authorHasselmo, Michael E.en_US
dc.date.accessioned2020-05-07T15:58:17Z
dc.date.available2020-05-07T15:58:17Z
dc.date.issued2013-06-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319509600016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationMark P. Brandon, Andrew R. Bogaard, Nathan W. Schultheiss, Michael E. Hasselmo. 2013. "Segregation of cortical head direction cell assemblies on alternating theta cycles." NATURE NEUROSCIENCE, Volume 16, Issue 6, https://doi.org/10.1038/nn.3383
dc.identifier.issn1097-6256
dc.identifier.urihttps://hdl.handle.net/2144/40675
dc.description.abstractHigh-level cortical systems for spatial navigation, including entorhinal grid cells, critically depend on input from the head direction system. We examined spiking rhythms and modes of synchrony between neurons participating in head direction networks for evidence of internal processing, independent of direct sensory drive, which may be important for grid cell function. We found that head direction networks of rats were segregated into at least two populations of neurons firing on alternate theta cycles (theta cycle skipping) with fixed synchronous or anti-synchronous relationships. Pairs of anti-synchronous theta cycle skipping neurons exhibited larger differences in head direction tuning, with a minimum difference of 40 degrees of head direction. Septal inactivation preserved the head direction signal, but eliminated theta cycle skipping of head direction cells and grid cell spatial periodicity. We propose that internal mechanisms underlying cycle skipping in head direction networks may be critical for downstream spatial computation by grid cells.en_US
dc.description.sponsorshipWe kindly thank S. Gillet, J. Hinman, E. Newman and L. Ewell for their invaluable consultations and comments on previous versions of this manuscript, as well as M. Connerney, S. Eriksson, C. Libby and T. Ware for technical assistance and behavioral training. This work was supported by grants from the National Institute of Mental Health (R01 MH60013 and MH61492) and the Office of Naval Research Multidisciplinary University Research Initiative (N00014-10-1-0936). (R01 MH60013 - National Institute of Mental Health; MH61492 - National Institute of Mental Health; N00014-10-1-0936 - Office of Naval Research Multidisciplinary University Research Initiative)en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature neuroscience
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectScience & technologyen_US
dc.subjectLife sciences & biomedicineen_US
dc.subjectNeurosciencesen_US
dc.subjectNeurologyen_US
dc.subjectFreely moving ratsen_US
dc.subjectHippocampal pyramidal cellsen_US
dc.subjectEntorhinal grid cellsen_US
dc.subjectMedial septal areaen_US
dc.subjectPhase precessionen_US
dc.subjectWorking-memoryen_US
dc.subjectOscillatory-interferenceen_US
dc.subjectGabaergic odulationen_US
dc.subjectRhythmen_US
dc.subjectPlaceen_US
dc.subjectAnimalsen_US
dc.subjectEntorhinal cortexen_US
dc.subjectHeaden_US
dc.subjectHippocampusen_US
dc.subjectMaleen_US
dc.subjectNerve neten_US
dc.subjectNeuronsen_US
dc.subjectOrientationen_US
dc.subjectPatch-clamp techniquesen_US
dc.subjectPeriodicityen_US
dc.subjectRatsen_US
dc.subjectSpace perceptionen_US
dc.subjectTheta rhythmen_US
dc.subjectNeurosurgeryen_US
dc.subjectNeurosciencesen_US
dc.subjectCognitive sciencesen_US
dc.subjectPsychologyen_US
dc.titleSegregation of cortical head direction cell assemblies on alternating theta cyclesen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1038/nn.3383
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Psychological & Brain Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-9925-6377 (Hasselmo, Michael E)
dc.identifier.mycv34369


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