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dc.contributor.advisorZhang, Xinen_US
dc.contributor.authorYuan, Fanen_US
dc.date.accessioned2020-05-08T17:04:13Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/2144/40715
dc.description.abstractIn order to calculate specific impedance of cell-covered electrodes in a Equation of morphological parameters of cell per se, an ECIS model of Human Renal Epithelial Cell are created by analysis partial differential equations describing three intrinsic pathways of electrical currents in the system. Based on this cell model, this research explores how some adjustable dimensional parameters of electrode-configuration impact sensor sensitivity by changing the overall impedance contribution of electrical double layer. Namely, it includes electrode planner area, spacing between working and counter electrode and geometry of electrode, scanning frequency. Qualitative studies on how sensor sensitivity rely on configurational parameters are conducted with these parameters involved. Moreover, theoretical analysis of sensitivity by using equivalent circuit model is also carried out. As results of COMSOL simulations, special double layer electrode configurations and selectively planted cell monolayer arrangement are proposed regardless of fabrication difficulties. Accordingly, some possible strategies to make these arrangements come true are also illustrated. Finally, superior possible COMSOL simulation model is suggested and discussed for future optimization works.en_US
dc.language.isoen_US
dc.subjectBioengineeringen_US
dc.subjectCOMSOL simulationen_US
dc.subjectFinite element analysisen_US
dc.subjectHuman renal epithelial cellen_US
dc.subjectMicroelectrode sensoren_US
dc.subjectReal-time monitoringen_US
dc.subjectSensor sensitivityen_US
dc.titleOptimization of microelectrode sensor sensitivity for real-time monitoring important physiological parameters of human renal epithelial cellen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2020-05-07T22:02:15Z
dc.description.embargo2021-05-07T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMaterials Science & Engineeringen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1174-2283


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