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dc.contributor.authorGoldford, Joshua E.en_US
dc.contributor.authorLu, Nanxien_US
dc.contributor.authorBajic, Djordjeen_US
dc.contributor.authorEstrela, Sylvieen_US
dc.contributor.authorTikhonov, Mikhailen_US
dc.contributor.authorSanchez-Gorostiaga, Aliciaen_US
dc.contributor.authorSegre, Danielen_US
dc.contributor.authorMehta, Pankajen_US
dc.contributor.authorSanchez, Alvaroen_US
dc.date.accessioned2020-05-14T18:34:53Z
dc.date.available2020-05-14T18:34:53Z
dc.date.issued2018-08-03
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000440627300034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationJoshua E Goldford, Nanxi Lu, Djordje Bajic, Sylvie Estrela, Mikhail Tikhonov, Alicia Sanchez-Gorostiaga, Daniel Segre, Pankaj Mehta, Alvaro Sanchez. 2018. "Emergent simplicity in microbial community assembly." Science, Volume 361, Issue 6401, pp. 469 - 474. https://doi.org/10.1126/science.aat1168
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttps://hdl.handle.net/2144/40874
dc.descriptionPublished in final edited form as: Science. 2018 August 03; 361(6401): 469–474. doi:10.1126/science.aat1168.en_US
dc.description.abstractA major unresolved question in microbiome research is whether the complex taxonomic architectures observed in surveys of natural communities can be explained and predicted by fundamental, quantitative principles. Bridging theory and experiment is hampered by the multiplicity of ecological processes that simultaneously affect community assembly in natural ecosystems. We addressed this challenge by monitoring the assembly of hundreds of soil- and plant-derived microbiomes in well-controlled minimal synthetic media. Both the community-level function and the coarse-grained taxonomy of the resulting communities are highly predictable and governed by nutrient availability, despite substantial species variability. By generalizing classical ecological models to include widespread nonspecific cross-feeding, we show that these features are all emergent properties of the assembly of large microbial communities, explaining their ubiquity in natural microbiomes.en_US
dc.description.sponsorshipThe funding for this work partly results from a Scialog Program sponsored jointly by the Research Corporation, for Science Advancement and. the Gordon and Betty Moore Foundation through grants to Yale University and Boston University by the Research Corporation and by the Simons Foundation. This work was also supported by a young; investigator award from the Human Frontier Science Program to A.S. (RGY0077/2016) and by NIH NIGMS grant 1R35GM119461 and a Simons Investigator as in the Mathematical Modeling of Living Systems (MMLS) to P.M.; D.S. and J.E.G. additionally acknowledge funding from the Defense Advanced Research Projects Agency (purchase request no. HR0011515303, contract no.. HR0011-15-0-0091), the U.S. Department of Energy (DE-SC0012627), the NIH (T32GM100842, 5R01DE024468, R01GM121950, and Sub_P30DK036836_P&F), the National Science Foundation (1457695), the Human Frontier Science Program (RGP0020/2016) and the Boston University Interdisciplinary Biomedical Research Office. (Research Corporation, for Science Advancement; Gordon and Betty Moore Foundation; Boston University by the Research Corporation; Simons Foundation.; RGY0077/2016 - uman Frontier Science Program; 1R35GM119461 - NIH NIGMS grant; Simons Investigator as in the Mathematical Modeling of Living Systems (MMLS); HR0011515303 - Defense Advanced Research Projects Agency; HR0011-15-0-0091 - Defense Advanced Research Projects Agency; T32GM100842 - NIH; 5R01DE024468 - NIH; R01GM121950 - NIH; ub_P30DK036836 - NIH; 1457695 - National Science Foundation; RGP0020/2016 - Human Frontier Science Program; Boston University Interdisciplinary Biomedical Research Office)en_US
dc.format.extentp. 469 - 474en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherAMER ASSOC ADVANCEMENT SCIENCEen_US
dc.relation.ispartofSCIENCE
dc.subjectScience & technologyen_US
dc.subjectBacteriaen_US
dc.subjectMicrobial consortiaen_US
dc.subjectPlantsen_US
dc.subjectSoil microbiologyen_US
dc.subjectBacteriaen_US
dc.subjectPlantsen_US
dc.titleEmergent simplicity in microbial community assemblyen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1126/science.aat1168
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Biologyen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Physicsen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-4859-1914 (Segre, Daniel)
dc.identifier.mycv396408


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