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dc.contributor.authorOrtega-Martinez, Antonioen_US
dc.contributor.authorZimmermann, Bernharden_US
dc.contributor.authorCheng, Xiaojunen_US
dc.contributor.authorLi, Xingeen_US
dc.contributor.authorYucel, Meryem Ayşeen_US
dc.contributor.authorBoas, David A.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2019-10-10
dc.date.accessioned2020-05-14T18:35:36Z
dc.date.available2020-05-14T18:35:36Z
dc.date.issued2019-10
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31668028
dc.identifier.citationAntonio Ortega-Martinez, Bernhard Zimmermann, Xiaojun Cheng, Xinge Li, Meryem Ayşe Yucel, David A Boas. 2019. "Contribution of speckle noise in near-infrared spectroscopy measurements." J Biomed Opt, Volume 24, Issue 10, pp. 1 - 6. https://doi.org/10.1117/1.JBO.24.10.105003
dc.identifier.issn1560-2281
dc.identifier.urihttps://hdl.handle.net/2144/40875
dc.description.abstractNear-infrared spectroscopy (NIRS) is widely used in biomedical optics with applications ranging from basic science, such as in functional neuroimaging, to clinical, as in pulse oximetry. Despite the relatively low absorption of tissue in the near-infrared, there is still a significant amount of optical attenuation produced by the highly scattering nature of tissue. Because of this, designers of NIRS systems have to balance source optical power and source–detector separation to maximize the signal-to-noise ratio (SNR). However, theoretical estimations of SNR neglect the effects of speckle. Speckle manifests as fluctuations of the optical power received at the detector. These fluctuations are caused by interference of the multiple random paths taken by photons in tissue. We present a model for the NIRS SNR that includes the effects of speckle. We performed experimental validations with a NIRS system to show that it agrees with our model. Additionally, we performed computer simulations based on the model to estimate the contribution of speckle noise for different collection areas and source–detector separations. We show that at short source–detector separation, speckle contributes most of the noise when using long coherence length sources. Considering this additional noise is especially important for hybrid applications that use NIRS and speckle contrast simultaneously, such as in diffuse correlation spectroscopy.en_US
dc.description.sponsorshipR01 EB025145 - NIBIB NIH HHS; R24 NS104096 - NINDS NIH HHSen_US
dc.format.extentp. 1 - 6en_US
dc.languageeng
dc.language.isoen_US
dc.publisherSPIEen_US
dc.relation.ispartofJournal of Biomedical Optics
dc.rights© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDiffuse correlation spectroscopyen_US
dc.subjectNear-infrared spectroscopyen_US
dc.subjectNoise modelen_US
dc.subjectSpeckleen_US
dc.subjectOpticsen_US
dc.subjectOptical physicsen_US
dc.subjectOpthalmology and optometryen_US
dc.subjectBiomedical engineeringen_US
dc.titleContribution of speckle noise in near-infrared spectroscopy measurementsen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1117/1.JBO.24.10.105003
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.identifier.mycv490328


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© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Except where otherwise noted, this item's license is described as © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.