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dc.contributor.authorGoldford, Joshua E.en_US
dc.contributor.authorHartman, Hymanen_US
dc.contributor.authorMarsland, Roberten_US
dc.contributor.authorSegrè, Danielen_US
dc.coverage.spatialEnglanden_US
dc.date2019-09-27
dc.date.accessioned2020-05-14T18:38:53Z
dc.date.available2020-05-14T18:38:53Z
dc.date.issued2019-12
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31712697
dc.identifier.citationJoshua E Goldford, Hyman Hartman, Robert Marsland, Daniel Segrè. 2019. "Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism.." Nat Ecol Evol, Volume 3, Issue 12, pp. 1715 - 1724. https://doi.org/10.1038/s41559-019-1018-8
dc.identifier.issn2397-334X
dc.identifier.urihttps://hdl.handle.net/2144/40876
dc.descriptionPublished in final edited form as: Nat Ecol Evol. 2019 December ; 3(12): 1715–1724. doi:10.1038/s41559-019-1018-8.en_US
dc.description.abstractIt has been suggested that a deep memory of early life is hidden in the architecture of metabolic networks, whose reactions could have been catalyzed by small molecules or minerals before genetically encoded enzymes. A major challenge in unravelling these early steps is assessing the plausibility of a connected, thermodynamically consistent proto-metabolism under different geochemical conditions, which are still surrounded by high uncertainty. Here we combine network-based algorithms with physico-chemical constraints on chemical reaction networks to systematically show how different combinations of parameters (temperature, pH, redox potential and availability of molecular precursors) could have affected the evolution of a proto-metabolism. Our analysis of possible trajectories indicates that a subset of boundary conditions converges to an organo-sulfur-based proto-metabolic network fuelled by a thioester- and redox-driven variant of the reductive tricarboxylic acid cycle that is capable of producing lipids and keto acids. Surprisingly, environmental sources of fixed nitrogen and low-potential electron donors are not necessary for the earliest phases of biochemical evolution. We use one of these networks to build a steady-state dynamical metabolic model of a protocell, and find that different combinations of carbon sources and electron donors can support the continuous production of a minimal ancient 'biomass' composed of putative early biopolymers and fatty acids.en_US
dc.description.sponsorship80NSSC17K0295 - Intramural NASA; 80NSSC17K0296 - Intramural NASA; T32 GM100842 - NIGMS NIH HHSen_US
dc.format.extentp. 1715 - 1724en_US
dc.languageeng
dc.relation.ispartofNat Ecol Evol
dc.subjectBiomassen_US
dc.subjectCarbonen_US
dc.subjectCitric acid cycleen_US
dc.subjectMetabolic networks and pathwaysen_US
dc.subjectSulfuren_US
dc.subjectCarbonen_US
dc.titleEnvironmental boundary conditions for the origin of life converge to an organo-sulfur metabolismen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1038/s41559-019-1018-8
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, Administrationen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Biologyen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv493995


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