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dc.contributor.authorLancet, Doronen_US
dc.contributor.authorSegrè, Danielen_US
dc.contributor.authorKahana, Amiten_US
dc.coverage.spatialSwitzerlanden_US
dc.date2019-09-10
dc.date.accessioned2020-05-14T18:43:37Z
dc.date.available2020-05-14T18:43:37Z
dc.date.issued2019-09-20
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31547028
dc.identifier.citationDoron Lancet, Daniel Segrè, Amit Kahana. 2019. "Twenty Years of "Lipid World": A Fertile Partnership with David Deamer.." Life (Basel), Volume 9, Issue 4, https://doi.org/10.3390/life9040077
dc.identifier.issn2075-1729
dc.identifier.urihttps://hdl.handle.net/2144/40877
dc.description.abstract"The Lipid World" was published in 2001, stemming from a highly effective collaboration with David Deamer during a sabbatical year 20 years ago at the Weizmann Institute of Science in Israel. The present review paper highlights the benefits of this scientific interaction and assesses the impact of the lipid world paper on the present understanding of the possible roles of amphiphiles and their assemblies in the origin of life. The lipid world is defined as a putative stage in the progression towards life's origin, during which diverse amphiphiles or other spontaneously aggregating small molecules could have concurrently played multiple key roles, including compartment formation, the appearance of mutually catalytic networks, molecular information processing, and the rise of collective self-reproduction and compositional inheritance. This review brings back into a broader perspective some key points originally made in the lipid world paper, stressing the distinction between the widely accepted role of lipids in forming compartments and their expanded capacities as delineated above. In the light of recent advancements, we discussed the topical relevance of the lipid worldview as an alternative to broadly accepted scenarios, and the need for further experimental and computer-based validation of the feasibility and implications of the individual attributes of this point of view. Finally, we point to possible avenues for exploring transition paths from small molecule-based noncovalent structures to more complex biopolymer-containing proto-cellular systems.en_US
dc.description.sponsorship711473 - Minerva Foundation; 80NSSC17K0295, 80NSSC17K0296, 1724150 - National Science Foundationen_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofLife (Basel)
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGARDen_US
dc.subjectLipid Worlden_US
dc.subjectCompositional inheritanceen_US
dc.subjectMicelleen_US
dc.subjectOrigin of lifeen_US
dc.subjectSystems chemistryen_US
dc.subjectSystems protobiologyen_US
dc.subjectLipid Worlden_US
dc.subjectDeamer, Daviden_US
dc.titleTwenty years of "Lipid World": a fertile partnership with David Deameren_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.3390/life9040077
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Biologyen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.mycv488546


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.