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dc.contributor.authorJones, Roberten_US
dc.contributor.authorGrisot, Giorgiaen_US
dc.contributor.authorAugustinack, Jeanen_US
dc.contributor.authorMagnain, Carolineen_US
dc.contributor.authorBoas, David A.en_US
dc.contributor.authorFischl, Bruceen_US
dc.contributor.authorWang, Huien_US
dc.contributor.authorYendiki, Anastasiaen_US
dc.coverage.spatialUnited Statesen_US
dc.date2020-03-03
dc.date.accessioned2020-05-14T20:00:43Z
dc.date.available2020-05-14T20:00:43Z
dc.date.issued2020-03-06
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/32151760
dc.identifier.citationRobert Jones, Giorgia Grisot, Jean Augustinack, Caroline Magnain, David A Boas, Bruce Fischl, Hui Wang, Anastasia Yendiki. 2020. "Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain.." Neuroimage, Volume 214:116704. https://doi.org/10.1016/j.neuroimage.2020.116704
dc.identifier.issn1095-9572
dc.identifier.urihttps://hdl.handle.net/2144/40891
dc.description.abstractIn the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid sampling scheme. Our results suggest that current dMRI reconstruction approaches do not benefit substantially from ultra-high b-values or from very large numbers of diffusion-encoding directions. We also show that accuracy remains stable across dMRI voxel sizes of 1 ​mm or smaller but degrades at 2 ​mm, particularly in areas of complex white-matter architecture. We also show that, as the spatial resolution is reduced, axonal configurations in a dMRI voxel can no longer be modeled as a small set of distinct axon populations, violating an assumption that is sometimes made by dMRI reconstruction techniques. Our findings have implications for in vivo studies and illustrate the value of PSOCT as a source of ground-truth measurements of white-matter organization that does not suffer from the distortions typical of histological techniques.en_US
dc.format.extent20 pagesen_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofNeuroimage
dc.rightsCopyright © 2020 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMedical and health sciencesen_US
dc.subjectPsychology and cognitive sciencesen_US
dc.subjectNeurology & neurosurgeryen_US
dc.titleInsight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brainen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1016/j.neuroimage.2020.116704
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0002-6709-7711 (Boas, David A)
dc.identifier.mycv552786


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Copyright © 2020 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.
Except where otherwise noted, this item's license is described as Copyright © 2020 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license.