Epigenetic treatment of dermatologic disorders

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Date Issued
2019-09
Publisher Version
10.1002/ddr.21562
Author(s)
Moos, Walter H.
Faller, Douglas V.
Glavas, Ioannis P.
Harpp, David N.
Kanara, Iphigenia
Pinkert, Carl A.
Powers, Whitney R.
Sampani, Konstantina
Steliou, Kosta
Vavvas, Demetrios G.
Kodukula, Krishna
Zamboni, Robert J.
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Embargoed until:
2031-01-01
Permanent Link
https://hdl.handle.net/2144/40917
Version
Accepted manuscript
Citation (published version)
Walter H Moos, Douglas V Faller, Ioannis P Glavas, David N Harpp, Iphigenia Kanara, Carl A Pinkert, Whitney R Powers, Konstantina Sampani, Kosta Steliou, Demetrios G Vavvas, Krishna Kodukula, Robert J Zamboni. 2019. "Epigenetic treatment of dermatologic disorders." Drug Development Research, Volume 80, Issue 6, pp. 702 - 713. https://doi.org/10.1002/ddr.21562
Abstract
Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and other plant and vegetable extracts,have shown utility in treating skin and related diseases as well as conditioning the skin to maintain its healthy function. Powerful agents targeting nuclear regulatory pathways continue to hold promise as new or repurposed therapies for a wide variety of ills and skin conditions. Epigenetic approaches that activate Nrf2 to effect detoxification, redox balance, DNA repair and mitochondrial function are noteworthy. Some of the disease applications being actively investigated range from eczema and psoriasis to skin cancer and diabetes-related wound healing to name just a few
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