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dc.contributor.authorChern, Margareten_US
dc.contributor.authorKays, Joshua C.en_US
dc.contributor.authorBhuckory, Shashien_US
dc.contributor.authorDennis, Allison M.en_US
dc.date.accessioned2020-05-18T19:22:56Z
dc.date.available2020-05-18T19:22:56Z
dc.date.issued2019-01-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000456874900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationMargaret Chern, Joshua C Kays, Shashi Bhuckory, Allison M Dennis. 2019. "Sensing with photoluminescent semiconductor quantum dots." METHODS AND APPLICATIONS IN FLUORESCENCE, Volume 7, Issue 1, 36 pp. https://doi.org/10.1088/2050-6120/aaf6f8
dc.identifier.issn2050-6120
dc.identifier.urihttps://hdl.handle.net/2144/40973
dc.description.abstractFluorescent sensors benefit from high signal-to-noise and multiple measurement modalities, enabling a multitude of applications and flexibility of design. Semiconductor nanocrystal quantum dots (QDs) are excellent fluorophores for sensors because of their extraordinary optical properties. They have high thermal and photochemical stability compared to organic dyes or fluorescent proteins and are extremely bright due to their large molar cross-sections. In contrast to organic dyes, QD emission profiles are symmetric, with relatively narrow bandwidths. In addition, the size tunability of their emission color, which is a result of quantum confinement, make QDs exceptional emitters with high color purity from the ultra-violet to near infrared wavelength range. The role of QDs in sensors ranges from simple fluorescent tags, as used in immunoassays, to intrinsic sensors that utilize the inherent photophysical response of QDs to fluctuations in temperature, electric field, or ion concentration. In more complex configurations, QDs and biomolecular recognition moieties like antibodies are combined with a third component to modulate the optical signal via energy transfer. QDs can act as donors, acceptors, or both in energy transfer-based sensors using Förster resonance energy transfer (FRET), nanometal surface energy transfer (NSET), or charge or electron transfer. The changes in both spectral response and photoluminescent lifetimes have been successfully harnessed to produce sensitive sensors and multiplexed devices. While technical challenges related to biofunctionalization and the high cost of laboratory-grade fluorimeters have thus far prevented broad implementation of QD-based sensing in clinical or commercial settings, improvements in bioconjugation methods and detection schemes, including using simple consumer devices like cell phone cameras, are lowering the barrier to broad use of more sensitive QD-based devices.en_US
dc.format.extent36 pagesen_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherIOP PUBLISHING LTDen_US
dc.relation.ispartofMETHODS AND APPLICATIONS IN FLUORESCENCE
dc.rights"Statement of Provenance: A Creative Commons Licence, or any other form of open access licence, may not be attached to articles published under the subscription model. For example, authors may not post the Accepted Manuscript in non-commercial repositories or noncommercial Scientific Social Networks which automatically apply an open access licence to the article which grants reuse rights under the terms of the repository or Scientific Social Network."en_US
dc.subjectScience & technologyen_US
dc.subjectPhysical sciencesen_US
dc.subjectChemistry, analyticalen_US
dc.subjectChemistry, physicalen_US
dc.subjectELISAen_US
dc.subjectFLISAen_US
dc.subjectFRETen_US
dc.subjectIntrinsic sensoren_US
dc.subjectBiosensingen_US
dc.subjectFluorescent sensoren_US
dc.subjectRatiometric sensoren_US
dc.subjectResonance energy transferen_US
dc.subjectPhotoinduced electron-transferen_US
dc.subjectPortable fluorescence biosensoren_US
dc.subjectDual-emissionen_US
dc.subjectTemperature dependenceen_US
dc.subjectProteolytic activityen_US
dc.subjectGold nanoparticlesen_US
dc.subjectTurn-onen_US
dc.subjectSensitive detectionen_US
dc.subjectMetal nanoparticleen_US
dc.titleSensing with photoluminescent semiconductor quantum dotsen_US
dc.typeBook reviewen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1088/2050-6120/aaf6f8
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
dc.identifier.orcid0000-0001-5759-9905 (Dennis, Allison M)
dc.identifier.mycv407917


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