Show simple item record

dc.contributor.advisorMoussavi, Minaen_US
dc.contributor.advisorTaghian, Alphonse G.en_US
dc.contributor.authorHavens, Lauren Michaelen_US
dc.date.accessioned2020-06-05T17:49:10Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/2144/41132
dc.description.abstractPURPOSE: This study investigated the risk factors for cellulitis infection, the median time to onset of low volume swelling (5 to 10% relative volume change (RVC) and breast cancer-related lymphedema (BCRL) (≥10% RVC) after an incidence of cellulitis, and the impact of common risk factors of both cellulitis and lymphedema on low volume swelling and BCRL. METHODS: We reviewed electronic medical records of 98 patients who underwent unilateral breast cancer (BC) surgery in the year 2011, who had a presurgical baseline perometry measurement and at least two postsurgical follow-up measurements. Clinicopathologic data, edema, and cellulitis incidence were obtained by medical record review. RESULTS: 18.37% of patients (18/98) experienced at least one incidence of cellulitis at a median of 1.03 years postoperatively. Of those 18 patients, 44.44% (eight out of 18) developed low volume swelling and 11.11% (two out of 18) developed BCRL at a median of 1.08 years and 2.33 years postoperatively, respectively. The median time to cellulitis incidence was 0.94 years and 2.91 years after the onset of low volume swelling and BCLR, respectively. Univariate logistic regression revealed that regional lymph node radiation (RLNR) (OR 4.4; p = 0.032) and low volume swelling (OR 6.56; p = 0.004) are significant risk factors for BCRL. RLNR remained a significant risk factor for the development of BCRL by multivariate logistic regression (OR 9.43; p = 0.031). CONCLUSION: Cellulitis may not incite or worsen pre-existing BCRL or affect the median time to BCRL development. However, lymphedema may put patients at risk of cellulitis infection. Sample size may have precluded statistical significance and further research is required to definitively identify the effect of cellulitis infection on lymphedema risk.en_US
dc.language.isoen_US
dc.rightsAttribution 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMedicineen_US
dc.subjectBreast canceren_US
dc.subjectBreast cancer-related lymphedemaen_US
dc.subjectCellulitisen_US
dc.subjectLymphedemaen_US
dc.subjectUpper extremity cellulitisen_US
dc.titleCellulitis and breast cancer-related lymphedema: risk factors and timingen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2020-06-04T22:07:31Z
dc.description.embargo2022-06-04T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International