Boston University Libraries OpenBU
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    •   OpenBU
    • BU Open Access Articles
    • BU Open Access Articles
    • View Item
    •   OpenBU
    • BU Open Access Articles
    • BU Open Access Articles
    • View Item

    Effect of residual interatrial shunt on migraine burden after transcatheter closure of patent foramen ovale

    Thumbnail
    License
    Attribution-NonCommercial-ShareAlike 4.0 International
    Date Issued
    2020-02-10
    Publisher Version
    10.1016/j.jcin.2019.09.042
    Author(s)
    Ben-Assa, Eyal
    Rengifo-Moreno, Pablo
    Al-Bawardy, Rasha
    Kolte, Dhaval
    Cigarroa, Ricardo
    Cruz-Gonzalez, Ignacio
    Sakhuja, Rahul
    Elmariah, Sammy
    Pomerantsev, Eugene
    Vaina, Lucia M.
    Ning, MingMing
    Buonanno, Ferdinando S.
    Hung, Judy W.
    Inglessis, Ignacio
    Palacios, Igor F.
    Share to FacebookShare to TwitterShare by Email
    Export Citation
    Download to BibTex
    Download to EndNote/RefMan (RIS)
    Metadata
    Show full item record
    Permanent Link
    https://hdl.handle.net/2144/41140
    Version
    Accepted manuscript
    Citation (published version)
    Eyal Ben-Assa, Pablo Rengifo-Moreno, Rasha Al-Bawardy, Dhaval Kolte, Ricardo Cigarroa, Ignacio Cruz-Gonzalez, Rahul Sakhuja, Sammy Elmariah, Eugene Pomerantsev, Lucia M Vaina, MingMing Ning, Ferdinando S Buonanno, Judy W Hung, Ignacio Inglessis, Igor F Palacios. 2020. "Effect of residual interatrial shunt on migraine burden after transcatheter closure of patent foramen ovale." JACC Cardiovasc Interv, Volume 13, Issue 3, pp. 293 - 302. https://doi.org/10.1016/j.jcin.2019.09.042
    Abstract
    OBJECTIVES: This study sought to evaluate the long-term effect of transcatheter patent foramen ovale (PFO) closure on migraineurs with and without aura and examine the effect of residual right-to-left shunt. BACKGROUND: Many studies reported improvement in migraine symptoms after PFO closure, yet randomized trials failed to reach its clinical endpoints. METHODS: The study retrospectively analyzed data from 474 patients who underwent transcatheter PFO closure at Massachusetts General Hospital. Patients completed a migraine burden questionnaire at baseline and at follow-up. Migraine severity is reported as migraine frequency (days/month), average duration (min), and migraine burden (days × min/month). Improvement following closure was defined as complete abolishment of symptoms or >50% reduction in migraine burden. RESULTS: A total of 110 migraineurs who underwent PFO closure were included; 77.0% had aura and 23.0% were without aura, and 91.0% had a cryptogenic stroke. During long-term median follow-up of 3.2 (interquartile range: 2.1 to 4.9) years, there was a significant improvement in migraine symptoms in migraineurs with or without aura. Migraine burden was reduced by >50% in 87.0% of patients, and symptoms were completely abolished in 48%. Presence of aura was associated with abolishment of migraine (odds ratio: 4.30; 95% confidence interval: 1.50 to 12.30; p = 0.006). At 6 months after PFO closure, residual right-to-left shunt was present in 26% of patients. Absence of right-to-left shunt was associated with improvement in migraine burden by >50% (odds ratio: 4.60; 95% confidence interval: 1.30 to 16.10; p = 0.017). CONCLUSIONS: Long-term follow-up after transcatheter PFO closure was associated with significant improvement in migraine burden. Aura was a predictor of abolishing symptoms. Absence of residual right-to-left shunt was a predictor of significant reduction in migraine burden.
    Rights
    Attribution-NonCommercial-ShareAlike 4.0 International
    Collections
    • ENG: Biomedical Engineering: Scholarly Papers [268]
    • BU Open Access Articles [3666]


    Boston University
    Contact Us | Send Feedback | Help
     

     

    Browse

    All of OpenBUCommunities & CollectionsIssue DateAuthorsTitlesSubjectsThis CollectionIssue DateAuthorsTitlesSubjects

    Deposit Materials

    LoginNon-BU Registration

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Boston University
    Contact Us | Send Feedback | Help