Show simple item record

dc.contributor.authorBen-Assa, Eyalen_US
dc.contributor.authorRengifo-Moreno, Pabloen_US
dc.contributor.authorAl-Bawardy, Rashaen_US
dc.contributor.authorKolte, Dhavalen_US
dc.contributor.authorCigarroa, Ricardoen_US
dc.contributor.authorCruz-Gonzalez, Ignacioen_US
dc.contributor.authorSakhuja, Rahulen_US
dc.contributor.authorElmariah, Sammyen_US
dc.contributor.authorPomerantsev, Eugeneen_US
dc.contributor.authorVaina, Lucia M.en_US
dc.contributor.authorNing, MingMingen_US
dc.contributor.authorBuonanno, Ferdinando S.en_US
dc.contributor.authorHung, Judy W.en_US
dc.contributor.authorInglessis, Ignacioen_US
dc.contributor.authorPalacios, Igor F.en_US
dc.coverage.spatialUnited Statesen_US
dc.date2019-09-24
dc.date.accessioned2020-06-08T15:59:50Z
dc.date.available2020-06-08T15:59:50Z
dc.date.issued2020-02-10
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/32029246
dc.identifier.citationEyal Ben-Assa, Pablo Rengifo-Moreno, Rasha Al-Bawardy, Dhaval Kolte, Ricardo Cigarroa, Ignacio Cruz-Gonzalez, Rahul Sakhuja, Sammy Elmariah, Eugene Pomerantsev, Lucia M Vaina, MingMing Ning, Ferdinando S Buonanno, Judy W Hung, Ignacio Inglessis, Igor F Palacios. 2020. "Effect of residual interatrial shunt on migraine burden after transcatheter closure of patent foramen ovale." JACC Cardiovasc Interv, Volume 13, Issue 3, pp. 293 - 302. https://doi.org/10.1016/j.jcin.2019.09.042
dc.identifier.issn1876-7605
dc.identifier.urihttps://hdl.handle.net/2144/41140
dc.description.abstractOBJECTIVES: This study sought to evaluate the long-term effect of transcatheter patent foramen ovale (PFO) closure on migraineurs with and without aura and examine the effect of residual right-to-left shunt. BACKGROUND: Many studies reported improvement in migraine symptoms after PFO closure, yet randomized trials failed to reach its clinical endpoints. METHODS: The study retrospectively analyzed data from 474 patients who underwent transcatheter PFO closure at Massachusetts General Hospital. Patients completed a migraine burden questionnaire at baseline and at follow-up. Migraine severity is reported as migraine frequency (days/month), average duration (min), and migraine burden (days × min/month). Improvement following closure was defined as complete abolishment of symptoms or >50% reduction in migraine burden. RESULTS: A total of 110 migraineurs who underwent PFO closure were included; 77.0% had aura and 23.0% were without aura, and 91.0% had a cryptogenic stroke. During long-term median follow-up of 3.2 (interquartile range: 2.1 to 4.9) years, there was a significant improvement in migraine symptoms in migraineurs with or without aura. Migraine burden was reduced by >50% in 87.0% of patients, and symptoms were completely abolished in 48%. Presence of aura was associated with abolishment of migraine (odds ratio: 4.30; 95% confidence interval: 1.50 to 12.30; p = 0.006). At 6 months after PFO closure, residual right-to-left shunt was present in 26% of patients. Absence of right-to-left shunt was associated with improvement in migraine burden by >50% (odds ratio: 4.60; 95% confidence interval: 1.30 to 16.10; p = 0.017). CONCLUSIONS: Long-term follow-up after transcatheter PFO closure was associated with significant improvement in migraine burden. Aura was a predictor of abolishing symptoms. Absence of residual right-to-left shunt was a predictor of significant reduction in migraine burden.en_US
dc.format.extentp. 293 - 302en_US
dc.languageeng
dc.language.isoen_US
dc.publisherJACCen_US
dc.relation.ispartofJACC Cardiovasc Interv
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectMigraineen_US
dc.subjectPatent foramen ovaleen_US
dc.subjectRight-to-left shunten_US
dc.subjectCardiovascular system & hematologyen_US
dc.subjectCardiorespiratory medicine and haematologyen_US
dc.titleEffect of residual interatrial shunt on migraine burden after transcatheter closure of patent foramen ovaleen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1016/j.jcin.2019.09.042
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0002-5636-8352 (Vaina, Lucia M)
dc.identifier.mycv530900


This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International