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dc.contributor.authorZikopoulos, Basilisen_US
dc.contributor.authorBarbas, Helenen_US
dc.date.accessioned2020-06-30T15:07:45Z
dc.date.available2020-06-30T15:07:45Z
dc.date.issued2007-09-05
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207455500031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationBasilis Zikopoulos, Helen Barbas. 2007. "Parallel Driving and Modulatory Pathways Link the Prefrontal Cortex and Thalamus." PLOS ONE, Volume 2, Issue 9, 19 pp. https://doi.org/10.1371/journal.pone.0000848
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/2144/41260
dc.description.abstractPathways linking the thalamus and cortex mediate our daily shifts from states of attention to quiet rest, or sleep, yet little is known about their architecture in high-order neural systems associated with cognition, emotion and action. We provide novel evidence for neurochemical and synaptic specificity of two complementary circuits linking one such system, the prefrontal cortex with the ventral anterior thalamic nucleus in primates. One circuit originated from the neurochemical group of parvalbumin-positive thalamic neurons and projected focally through large terminals to the middle cortical layers, resembling ‘drivers’ in sensory pathways. Parvalbumin thalamic neurons, in turn, were innervated by small ‘modulatory’ type cortical terminals, forming asymmetric (presumed excitatory) synapses at thalamic sites enriched with the specialized metabotropic glutamate receptors. A second circuit had a complementary organization: it originated from the neurochemical group of calbindin-positive thalamic neurons and terminated through small ‘modulatory’ terminals over long distances in the superficial prefrontal layers. Calbindin thalamic neurons, in turn, were innervated by prefrontal axons through small and large terminals that formed asymmetric synapses preferentially at sites with ionotropic glutamate receptors, consistent with a driving pathway. The largely parallel thalamo-cortical pathways terminated among distinct and laminar-specific neurochemical classes of inhibitory neurons that differ markedly in inhibitory control. The balance of activation of these parallel circuits that link a high-order association cortex with the thalamus may allow shifts to different states of consciousness, in processes that are disrupted in psychiatric diseases.en_US
dc.description.sponsorshipSupported by NIH grants from NIMH and NINDS. The authors declare no financial interest in this manuscript. (NIMH; NINDS)en_US
dc.format.extent19 pagesen_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.relation.ispartofPLOS ONE
dc.rightsCopyright: © 2007 Zikopoulos, Barbas. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectScience & technologyen_US
dc.subjectMultidisciplinary sciencesen_US
dc.subjectMetabotropic glutamate receptorsen_US
dc.subjectLateral geniculate-nucleusen_US
dc.subjectPrimary auditory cortexen_US
dc.subjectPrimary visual cortexen_US
dc.subjectNeurons in-vitroen_US
dc.subjectRhesus monkeyen_US
dc.subjectMacaque monkeyen_US
dc.subjectBasal gangliaen_US
dc.subjectCorticocortical communicationen_US
dc.subjectCorticothalamic projectionsen_US
dc.subjectAnimalsen_US
dc.subjectExcitatory postsynaptic potentialsen_US
dc.subjectMacaca mulattaen_US
dc.subjectNeuronsen_US
dc.subjectPrefrontal cortexen_US
dc.subjectSynapsesen_US
dc.subjectThalamusen_US
dc.titleParallel driving and modulatory pathways link the prefrontal cortex and thalamusen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1371/journal.pone.0000848
pubs.elements-sourceweb-of-scienceen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.orcid0000-0003-0825-0832 (Barbas, Helen)
dc.identifier.mycv106785


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Copyright: © 2007 Zikopoulos, Barbas. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright: © 2007 Zikopoulos, Barbas. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.