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dc.contributor.advisorOhira, Taisukeen_US
dc.contributor.authorAlsendi, Maryam Abdulazizen_US
dc.date.accessioned2020-07-30T13:13:22Z
dc.date.available2020-07-30T13:13:22Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/2144/41342
dc.description.abstractOBJECTIVE: To determine the effect of anti-inflammatory drugs (4- methoxybenzophenone) and (kavain) on bone formation and bone resorption models using a three-dimensional (3D) live calvarial bone METHODS: Utilizing neonatal mouse calvarial bones on a grid system with media designed to cause bone formation or resorption. These models were used to study the effect of 4- methoxybenzophenone and kavain on bone remodeling. The spent media were evaluated by quantitative analysis of tartrate resistant acid phosphatase (TRAP), alkaline phosphatase (ALP) activity and calcium release. The calvaria were stained with neutral red and silver nitrate for histological analysis. RESULTS: Kavain and 4-methoxybenzophenone affected the calvarial bone remodeling by inhibiting resorption. Kavain stimulated bone formation as shown by ALP activity and prevented the transformation of macrophages into osteoclasts as shown by neutral red staining. Kavain prevented resorption as shown by silver nitrate staining. Histological examination of kavain treated bone showed new osteoid formation. The other factor, 4-methoxybenzophenone, had inconsistent effects on bone. Neutral red staining showed no osteoclast differentiation and silver nitrate staining showed no resorption. However calcium release increased in the resorption model and calcium uptake increased in the formation model. There was no effect on ALP or trap activities in either model.en_US
dc.language.isoen_US
dc.rightsAttribution 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDentistryen_US
dc.subjectAnti-inflammatory drugsen_US
dc.subjectBoneen_US
dc.subjectCalciumen_US
dc.subjectCalvariaen_US
dc.subjectFormationen_US
dc.subjectResorptionen_US
dc.titleThe effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial boneen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2020-07-29T16:02:20Z
etd.degree.nameMaster of Science in Designen_US
etd.degree.levelmastersen_US
etd.degree.disciplinePeriodontologyen_US
etd.degree.grantorBoston Universityen_US
dc.identifier.orcidmaryam-alsendi


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International