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dc.contributor.authorBater, Joricken_US
dc.contributor.authorLauer, Jacqueline M.en_US
dc.contributor.authorGhosh, Shibanien_US
dc.contributor.authorWebb, Patricken_US
dc.contributor.authorAgaba, Edgaren_US
dc.contributor.authorBashaasha, Bernarden_US
dc.contributor.authorTuryashemererwa, Florence M.en_US
dc.contributor.authorShrestha, Robinen_US
dc.contributor.authorDuggan, Christopher P.en_US
dc.date.accessioned2020-10-27T19:24:27Z
dc.date.available2020-10-27T19:24:27Z
dc.identifier.citationJorick Bater, Jacqueline M Lauer, Shibani Ghosh, Patrick Webb, Edgar Agaba, Bernard Bashaasha, Florence M Turyashemererwa, Robin Shrestha, Christopher P Duggan. "Predictors of low birth weight and preterm birth in rural Uganda: Findings from a birth cohort study." PLOS ONE, Volume 15, Issue 7, pp. e0235626 - e0235626. https://doi.org/10.1371/journal.pone.0235626
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/2144/41551
dc.description.abstractBACKGROUND: Approximately 20.5 million infants were born weighing <2500 g (defined as low birthweight or LBW) in 2015, primarily in low- and middle-income countries (LMICs). Infants born LBW, including those born preterm (<37 weeks gestation), are at increased risk for numerous consequences, including neonatal mortality and morbidity as well as suboptimal health and nutritional status later in life. The objective of this study was to identify predictors of LBW and preterm birth among infants in rural Uganda. METHODS: Data were derived from a prospective birth cohort study conducted from 2014–2016 in 12 districts across northern and southwestern Uganda. Birth weights were measured in triplicate to the nearest 0.1 kg by trained enumerators within 72 hours of delivery. Gestational age was calculated from the first day of last menstrual period (LMP). Associations between household, maternal, and infant characteristics and birth outcomes (LBW and preterm birth) were assessed using bivariate and multivariable logistic regression with stepwise, backward selection analyses. RESULTS: Among infants in the study, 4.3% were born LBW (143/3,337), and 19.4% were born preterm (744/3,841). In multivariable analysis, mothers who were taller (>150 cm) (adjusted Odds Ratio (aOR) = 0.42 (95% CI = 0.24, 0.72)), multigravida (aOR = 0.62 (95% CI = 0.39, 0.97)), or with adequate birth spacing (>24 months) (aOR = 0.60 (95% CI = 0.39, 0.92)) had lower odds of delivering a LBW infant Mothers with severe household food insecurity (aOR = 1.84 (95% CI = 1.22, 2.79)) or who tested positive for malaria during pregnancy (aOR = 2.06 (95% CI = 1.10, 3.85)) had higher odds of delivering a LBW infant. In addition, in multivariable analysis, mothers who resided in the Southwest (aOR = 0.64 (95% CI = 0.54, 0.76)), were ≥20 years old (aOR = 0.76 (95% CI = 0.61, 0.94)), with adequate birth spacing (aOR = 0.76 (95% CI = 0.63, 0.93)), or attended ≥4 antenatal care (ANC) visits (aOR = 0.56 (95% CI = 0.47, 0.67)) had lower odds of delivering a preterm infant; mothers who were neither married nor cohabitating (aOR = 1.42 (95% CI = 1.00, 2.00)) or delivered at home (aOR = 1.25 (95% CI = 1.04, 1.51)) had higher odds. CONCLUSIONS: In rural Uganda, severe household food insecurity, adolescent pregnancy, inadequate birth spacing, malaria infection, suboptimal ANC attendance, and home delivery represent modifiable risk factors associated with higher rates of LBW and/or preterm birth. Future studies on interventions to address these risk factors may be warranted.en_US
dc.format.extentp. e0235626 - e0235626en_US
dc.languageen
dc.language.isoen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.relation.ispartofPLOS ONE
dc.rightsCopyright: © 2020 Bater et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectGeneral science & technologyen_US
dc.titlePredictors of low birth weight and preterm birth in rural Uganda: findings from a birth cohort studyen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1371/journal.pone.0235626
pubs.elements-sourcecrossrefen_US
pubs.notesEmbargo: No embargoen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusPublished onlineen_US
dc.date.online2020-07-13
dc.identifier.mycv571897


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Copyright: © 2020 Bater et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as Copyright: © 2020 Bater et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.