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dc.contributor.authorMesa, Mayra L.en_US
dc.date.accessioned2020-11-05T16:30:06Z
dc.date.available2020-11-05T16:30:06Z
dc.date.issued1974
dc.date.submitted1974
dc.identifier.other(OCoLC)16116109
dc.identifier.otherb14341633
dc.identifier.urihttps://hdl.handle.net/2144/41618
dc.descriptionPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.en_US
dc.descriptionix, 66 pages illustrations, color photomicrographs.en_US
dc.descriptionThesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1974. Oral pathology.en_US
dc.descriptionBibliography included.en_US
dc.description.abstractAn experimental histomorphologic study was carried out to observe the differentiation and development of embryonic intraoral tissues isologously implanted into adult hamster cheek pouches. Twelve inbred adult male Syrian hamsters were challenged with solid intrapouch brephoplastic homografts, the tissues obtained from sectioning fetal mandibles and maxillae. A series of histological changes were observed during the study period of 22 weeks. Biocellular differentiation and modulation effects were reflected in the production of keratinizing epithelial cysts, bone marrow development with an exuberant proliferation of hematopoietic elements, atypical tooth-like structure, cartilagenous proliferation, formation of sebaceous units, and osseous metaplasia of collagenic aggregates. A notable observation was the transitory nature of the more subspecialized tissue forms. Dedifferential modulation to non-specialized cell types following initial persistence and proliferation of specifically directed cell lines, derived from the primitive tissues, was observed during the timecourse of the implants. Complete loss of tissue-unit integrity of some cell lines was ascribed to the qualitative and quantitative immaturity of certain cellular types in a non-inductive environment. Persistence and proliferation solely of keratohyalin synthetizing epithelium, implies a metabolic versatility of this basic cell type, and a “plateau-fixed” differential capacity, insofar as regression to a potentially more vulnerable basaloid cell line was not observed.en_US
dc.language.isoen_US
dc.publisherBoston Universityen_US
dc.rightsThis work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.en_US
dc.subjectDental Implantationen_US
dc.subjectTransplantation, Homologousen_US
dc.titleEffect of an inductively deprived tissue environment on subspecialized cell lines of brephoplastic oral implantsen_US
dc.typeThesis/Dissertationen_US
etd.degree.nameMaster of Science in Dentistryen_US
etd.degree.levelmastersen_US
etd.degree.disciplineOral Pathologyen_US
etd.degree.grantorBoston Universityen_US


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