The role of immune response in traumatic injury
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The host immune response to traumatic injury is complex with potentially serious consequences in certain situations. Research has shown that the immune system response after injury is dynamic with both arms of the immune system associated in the response. Building on existing work on trauma research, the exact mechanisms for how the immune system wreaks havoc in some trauma patients in the body’s attempt to restore homeostasis is not fully understood. An immunological cascade initiated after injury by certain innate immune cells has been indicated as the main catalyst for serious complications after trauma in SIRS (Systemic Inflammatory Response Syndrome). SIRS, a serious medical complication with inflammation throughout the body, is often associated with other conditions such as multiorgan failure leading to death. Early treatment and medical intervention are imperative in increasing the survival chances in those with severe complications. Despite the advances in medicine in the last few decades, therapeutic solutions to address these issues are still ongoing given the complex workings of the host immune system. This review aims to examine the immune response in various types of injuries, post injury impacts, current treatments, and ongoing research aimed at developing better therapeutic strategies.