Show simple item record

dc.contributor.advisorBissonnette, Stephanieen_US
dc.contributor.authorVazquez, Gabriellaen_US
dc.date.accessioned2021-03-05T16:38:53Z
dc.date.available2021-03-05T16:38:53Z
dc.date.issued2020
dc.identifier.urihttps://hdl.handle.net/2144/42210
dc.description.abstractParkinson’s Disease (PD) is a neurological movement disorder characterized by depletion of dopaminergic cell bodies in the substantia nigra pars compacta with subsequent loss of dopamine in the nigrostriatal pathway. PD is definitively diagnosed by the presence of intracytoplasmic inclusions in dopaminergic neurons. These inclusions are composed of a-synuclein aggregates, known as “Lewy bodies.” Lewy Bodies are known to be toxic to neurons leading to cell death. Individuals with PD most commonly manifest with bradykinesia (slowness in movement), tremors, and rigidity, but may also suffer orthostatic hypotension, dysphagia, anosmia, constipation, and sleep dysregulation. Mechanisms of PD pathogenesis may include defective protein handling, mitochondrial dysfunction, oxidative stress, and inflammation. Exposure to pesticides has long been implicated in the etiology of Parkinson’s Disease. An increasing number of epidemiological studies have linked the incidence of Parkinson’s Disease to environmental risk factors such as exposure to occupational pesticides and rural living where pesticides are known to leak into the soil and water systems far from their original area of use. The epidemiologic literature is lacking studies with large enough cohorts and accurate means to measure the exact pesticide exposure and duration of exposure. Given the extensive worldwide use of pesticides it is important to further study the associations between Parkinson’s disease and occupation exposures in larger populations.en_US
dc.language.isoen_US
dc.subjectNeurosciencesen_US
dc.subjectParaquaten_US
dc.subjectParkinson's diseaseen_US
dc.subjectParkinsonismen_US
dc.subjectPesticidesen_US
dc.subjectRisken_US
dc.subjectRotenoneen_US
dc.titleThe association between pesticides and Parkinson's disease risken_US
dc.typeThesis/Dissertationen_US
dc.date.updated2021-03-01T23:01:58Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplinePhysician Assistant Programen_US
etd.degree.grantorBoston Universityen_US


This item appears in the following Collection(s)

Show simple item record