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    Design of a high-resolution light field miniscope for volumetric imaging in scattering tissue

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    Date Issued
    2020
    Author(s)
    Chen, Yanqin
    Xiong, Bo
    Xue, Yujia
    Jin, Xin
    Greene, Joseph
    Tian, Lei
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    Permanent Link
    https://hdl.handle.net/2144/42283
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    Citation (published version)
    Yanqin Chen, Bo Xiong, Yujia Xue, Xin Jin, Joseph Greene, Lei Tian. 2020. "Design of a high-resolution light field miniscope for volumetric imaging in scattering tissue." Biomedical Optics Express, Volume 11, pp. 1662 - 1678.
    Abstract
    Integrating light field microscopy techniques with existing miniscope architectures has allowed for volumetric imaging of targeted brain regions in freely moving animals. However, the current design of light field miniscopes is limited by non-uniform resolution and long imaging path length. In an effort to overcome these limitations, this paper proposes an optimized Galilean-mode light field miniscope (Gali-MiniLFM), which achieves a more consistent resolution and a significantly shorter imaging path than its conventional counterparts. In addition, this paper provides a novel framework that incorporates the anticipated aberrations of the proposed Gali-MiniLFM into the point spread function (PSF) modeling. This more accurate PSF model can then be used in 3D reconstruction algorithms to further improve the resolution of the platform. Volumetric imaging in the brain necessitates the consideration of the effects of scattering. We conduct Monte Carlo simulations to demonstrate the robustness of the proposed Gali-MiniLFM for volumetric imaging in scattering tissue.
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    © 2020 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
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