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dc.contributor.authorLevi-Galibov, Oshraten_US
dc.contributor.authorLavon, Hagaren_US
dc.contributor.authorWassermann-Dozorets, Rinaen_US
dc.contributor.authorPevsner-Fischer, Meiraven_US
dc.contributor.authorMayer, Shimriten_US
dc.contributor.authorWershof, Estheren_US
dc.contributor.authorStein, Yaniven_US
dc.contributor.authorBrown, Lauren E.en_US
dc.contributor.authorZhang, Wenhanen_US
dc.contributor.authorFriedman, Gilen_US
dc.contributor.authorNevo, Reinaten_US
dc.contributor.authorGolani, Ofraen_US
dc.contributor.authorKatz, Lior H.en_US
dc.contributor.authorYaeger, Ronaen_US
dc.contributor.authorLaish, Idoen_US
dc.contributor.authorPorco, John A.en_US
dc.contributor.authorSahai, Eriken_US
dc.contributor.authorShouval, Dror S.en_US
dc.contributor.authorKelsen, Daviden_US
dc.contributor.authorScherz-Shouval, Ruthen_US
dc.coverage.spatialEnglanden_US
dc.date2020-11-09
dc.date.accessioned2021-04-07T13:40:29Z
dc.date.available2021-04-07T13:40:29Z
dc.date.issued2020-12-07
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33288768
dc.identifier.citationOshrat Levi-Galibov, Hagar Lavon, Rina Wassermann-Dozorets, Meirav Pevsner-Fischer, Shimrit Mayer, Esther Wershof, Yaniv Stein, Lauren E Brown, Wenhan Zhang, Gil Friedman, Reinat Nevo, Ofra Golani, Lior H Katz, Rona Yaeger, Ido Laish, John A Porco, Erik Sahai, Dror S Shouval, David Kelsen, Ruth Scherz-Shouval. 2020. "Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer.." Nat Commun, Volume 11, Issue 1, pp. 6245 - ?. https://doi.org/10.1038/s41467-020-20054-x
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/2144/42360
dc.description.abstractIn the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While the causal and clinical links are well established, molecular understanding of how chronic inflammation leads to the development of colon cancer is lacking. Here we deconstruct the evolving microenvironment of CAC by measuring proteomic changes and extracellular matrix (ECM) organization over time in a mouse model of CAC. We detect early changes in ECM structure and composition, and report a crucial role for the transcriptional regulator heat shock factor 1 (HSF1) in orchestrating these events. Loss of HSF1 abrogates ECM assembly by colon fibroblasts in cell-culture, prevents inflammation-induced ECM remodeling in mice and inhibits progression to CAC. Establishing relevance to human disease, we find high activation of stromal HSF1 in CAC patients, and detect the HSF1-dependent proteomic ECM signature in human colorectal cancer. Thus, HSF1-dependent ECM remodeling plays a crucial role in mediating inflammation-driven colon cancer.en_US
dc.description.sponsorshipR35 GM118173 - NIGMS NIH HHS; U01 TR002625 - NCATS NIH HHS; P30 CA008748 - NCI NIH HHS; FC010144 - Cancer Research UK; FC010144 - Medical Research Council; FC010144 - Wellcome Trusten_US
dc.format.extentp. 6245en_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofNat Commun
dc.rights© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/.
dc.subjectAnimalsen_US
dc.subjectCell Line, tumoren_US
dc.subjectCells, cultureden_US
dc.subjectColitis-associated neoplasmsen_US
dc.subjectDisease models, animalen_US
dc.subjectExtracellular matrixen_US
dc.subjectHeat shock transcription factorsen_US
dc.subjectHumansen_US
dc.subjectMass spectrometryen_US
dc.subjectMice, 129 strainen_US
dc.subjectMice, inbred BALB Cen_US
dc.subjectMice, knockouten_US
dc.subjectProteomeen_US
dc.subjectProteomicsen_US
dc.titleHeat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon canceren_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1038/s41467-020-20054-x
pubs.elements-sourcepubmeden_US
pubs.notesEmbargo: Not knownen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Arts & Sciencesen_US
pubs.organisational-groupBoston University, College of Arts & Sciences, Department of Chemistryen_US
pubs.publication-statusPublished onlineen_US
dc.identifier.orcid0000-0001-9489-484X (Brown, Lauren E)
dc.identifier.mycv576594


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© The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Except where otherwise noted, this item's license is described as © The Author(s) 2020. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.