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dc.contributor.advisorVegas, Arturoen_US
dc.contributor.authorHou, Haoyien_US
dc.date.accessioned2021-09-28T17:49:19Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/2144/43085
dc.description.abstractAlginate is a widely used biomaterial for a variety of biomedical applications ranging from drug delivery to cell transplantation. The unique polysaccharide backbone endows the material with a number of useful properties such as hydrophilicity, biocompatibility, and gelation ability. Despite these advantages, one limitation for alginate is the lack of a tunable degradation rate, and its gels may only partially degrade and implants are not fully cleared from the body long after their purpose is fulfilled. To further extend the utility of this biomaterial, we hypothesized that by creating a polymer chimera between polylactic acid (PLA) and alginate we can integrate tunable degradation properties into alginate hydrogels. The alginate-b-PLA diblock copolymers were synthesized by utilizing an inverse electron demand Diels-Alder reaction, and were then fabricated into hydrogels using two approaches: doping with low viscosity alginate (LWA) and direct gelation. These hydrogel chimeras exhibited degradation rates that could be tuned from days to weeks. Morphologically, the combination of different domain sizes of alginate and PLA contributed to different microstructures within the hydrogel matrix that contributes to its degradability. Drug release was not impacted by matrix degradation rate, as four different encapsulated payloads of variable hydrophobicity and molecular weight were encapsulated with the chimeric hydrogels showed comparable release rates to non-degradable alginates. These new degradable alginates could have future utility as degradable drug-eluting implants.en_US
dc.language.isoen_US
dc.subjectMaterials scienceen_US
dc.subjectAlginateen_US
dc.subjectDrug deliveryen_US
dc.subjectHydrogelen_US
dc.subjectPolylactic aciden_US
dc.titlePreparation and characterization of alginate-b-PLA hydrogelsen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2021-09-25T02:10:56Z
dc.description.embargo2022-09-24T00:00:00Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMaterials Science & Engineeringen_US
etd.degree.grantorBoston Universityen_US


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