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dc.contributor.authorLiu, Xuefenden_US
dc.contributor.authorBautista, Julieden_US
dc.contributor.authorLiu, Edwarden_US
dc.contributor.authorZikopoulos, Vasileiosen_US
dc.coverage.spatialSan Diego, CAen_US
dc.date.accessioned2021-10-20T13:14:03Z
dc.date.available2021-10-20T13:14:03Z
dc.date.issued2018
dc.identifierhttps://www.abstractsonline.com/pp8/#!/4649/presentation/5921
dc.identifier.citationX. Liu, J. Bautista, E. Liu, V. Zikopoulos. "Balance of excitation and inhibition in orbitofrontal cortex and potential for disruption in autism." Society for Neuroscience. San Diego, CA, 2018-11-06 - 2018-11-06. https://www.abstractsonline.com/pp8/#!/4649/presentation/5921.
dc.identifier.urihttps://hdl.handle.net/2144/43189
dc.description.abstractThe human orbitofrontal cortex (OFC) is involved in assessing the emotional significance of events and stimuli, emotion based learning, allocation of attentional resources, and social cognition. Little is known about the structure, connectivity and excitatory/inhibitory circuit interactions underlying these diverse functions in human OFC. To fill this gap we used high resolution microscopy, followed by quantitative tracing analysis, to characterize the morphology and distribution of myelinated axons across cortical layers in human OFC at the single axon level, as a proxy of excitatory pathways. In the same regions, we also examined the laminar distribution of neurochemically- and functionally-distinct inhibitory neurons that express calcium-binding proteins parvalbumin (PV), calbindin (CB), and calretinin (CR). Associations of myelinated axons with distinct inhibitory neurons changed across layers and provided a proxy for the study of the excitatory/inhibitory ratio in OFC. We found that density of myelinated axons increased consistently towards layer VI, while average axon diameter did not change significantly. Inhibitory CR-positive neurons were mostly found in layer II, the layer with the lowest density of myelinated axons. CB-positive inhibitory neurons were most dense in layer II and upper layer III. PV-positive inhibitory neurons were mostly found in the middle/deep layers, especially lower layer III, among a dense plexus of myelinated axons, some of which also expressed PV, presumably coming from the thalamus. The balance between excitation and inhibition in OFC is at the core of OFC function. The OFC gets an overview of the sensory environment through feedforward cortical inputs and assesses the emotional significance of events, based on robust feedback input from the amygdala, in processes that are disrupted in autism spectrum disorder (ASD). We previously showed that in individuals with ASD, excitatory OFC pathways exhibit overall thinning of the myelin sheath of axons, which likely affects conduction velocity and neurotransmission. This suggests laminar-specific changes in the ratio of excitation/inhibition in OFC of individuals with ASD, and may provide the anatomic basis for disrupted transmission of signals for emotions.en_US
dc.language.isoen_US
dc.publisherSociety for Neuroscienceen_US
dc.titleBalance of excitation and inhibition in orbitofrontal cortex and potential for disruption in autismen_US
dc.typeConference materialsen_US
dc.description.versionPublished versionen_US
pubs.elements-sourcemanual-entryen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusPublished onlineen_US
dc.date.online2018
dc.identifier.mycv447733


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