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dc.contributor.authorGarcía-Cabezas, Miguel Ángelen_US
dc.contributor.authorZikopoulos, Basilisen_US
dc.contributor.authorBarbas, Helenen_US
dc.coverage.spatialGermanyen_US
dc.date2019-01-29
dc.date.accessioned2021-11-24T20:23:08Z
dc.date.available2021-11-24T20:23:08Z
dc.date.issued2019-04
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30739157
dc.identifier.citationM.Á. García-Cabezas, B. Zikopoulos, H. Barbas. 2019. "The Structural Model: a theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex.." Brain Struct Funct, Volume 224, Issue 3, pp. 985 - 1008. https://doi.org/10.1007/s00429-019-01841-9
dc.identifier.issn1863-2661
dc.identifier.urihttps://hdl.handle.net/2144/43414
dc.descriptionPublished in final edited form as: Brain Struct Funct. 2019 April ; 224(3): 985–1008. doi:10.1007/s00429-019-01841-9.en_US
dc.description.abstractThe classical theory of cortical systematic variation has been independently described in reptiles, monotremes, marsupials and placental mammals, including primates, suggesting a common bauplan in the evolution of the cortex. The Structural Model is based on the systematic variation of the cortex and is a platform for advancing testable hypotheses about cortical organization and function across species, including humans. The Structural Model captures the overall laminar structure of areas by dividing the cortical architectonic continuum into discrete categories (cortical types), which can be used to test hypotheses about cortical organization. By type, the phylogenetically ancient limbic cortices-which form a ring at the base of the cerebral hemisphere-are agranular if they lack layer IV, or dysgranular if they have an incipient granular layer IV. Beyond the dysgranular areas, eulaminate type cortices have six layers. The number and laminar elaboration of eulaminate areas differ depending on species or cortical system within a species. The construct of cortical type retains the topology of the systematic variation of the cortex and forms the basis for a predictive Structural Model, which has successfully linked cortical variation to the laminar pattern and strength of cortical connections, the continuum of plasticity and stability of areas, the regularities in the distribution of classical and novel markers, and the preferential vulnerability of limbic areas to neurodegenerative and psychiatric diseases. The origin of cortical types has been recently traced to cortical development, and helps explain the variability of diseases with an onset in ontogeny.en_US
dc.description.sponsorshipR01 MH057414 - NIMH NIH HHS; R01 MH101209 - NIMH NIH HHS; R01 MH101209 - National Institute of Mental Health; R01 MH057414 - National Institute of Mental Health; R01 MH117785 - NIMH NIH HHS; R01 MH117785 - National Institute of Mental Health; R01 NS024760 - National Institute of Neurological Disorders and Stroke (US); R01 NS024760 - NINDS NIH HHSen_US
dc.format.extent985 - 1008en_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofBrain Struct Funct
dc.subjectLimbic cortexen_US
dc.subjectCortical hierarchiesen_US
dc.subjectHomologyen_US
dc.subjectPhylogenyen_US
dc.subjectBrain pathologyen_US
dc.subjectGliaen_US
dc.titleThe Structural Model: a theory linking connections, plasticity, pathology, development and evolution of the cerebral cortexen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1007/s00429-019-01841-9
pubs.elements-sourcepubmeden_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv430452


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