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dc.contributor.authorGarcia-Cabezas, Miguel Ángelen_US
dc.contributor.authorJoyce, Mary Kate P.en_US
dc.contributor.authorJohn, Yohan J.en_US
dc.contributor.authorZikopoulos, Basilisen_US
dc.contributor.authorBarbas, Helenen_US
dc.date.accessioned2021-11-24T20:31:47Z
dc.date.available2021-11-24T20:31:47Z
dc.date.issued2017-10-01
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000412902700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=6e74115fe3da270499c3d65c9b17d654
dc.identifier.citationM.A. Garcia-Cabezas, M.K.P. Joyce, Y.J. John, B. Zikopoulos, H. Barbas. 2017. "Mirror trends of plasticity and stability indicators in primate prefrontal cortex." EUROPEAN JOURNAL OF NEUROSCIENCE, Volume 46, Issue 8, pp. 2392 - 2405. https://doi.org/10.1111/ejn.13706
dc.identifier.issn0953-816X
dc.identifier.issn1460-9568
dc.identifier.urihttps://hdl.handle.net/2144/43415
dc.descriptionPublished in final edited form as: Eur J Neurosci. 2017 October ; 46(8): 2392–2405. doi:10.1111/ejn.13706.en_US
dc.description.abstractResearch on plasticity markers in the cerebral cortex has largely focused on their timing of expression and role in shaping circuits during critical and normal periods. By contrast, little attention has been focused on the spatial dimension of plasticity–stability across cortical areas. The rationale for this analysis is based on the systematic variation in cortical structure that parallels functional specialization and raises the possibility of varying levels of plasticity. Here, we investigated in adult rhesus monkeys the expression of markers related to synaptic plasticity or stability in prefrontal limbic and eulaminate areas that vary in laminar structure. Our findings revealed that limbic areas are impoverished in three markers of stability: intracortical myelin, the lectin Wisteria floribunda agglutinin, which labels perineuronal nets, and parvalbumin, which is expressed in a class of strong inhibitory neurons. By contrast, prefrontal limbic areas were enriched in the enzyme calcium/calmodulin-dependent protein kinase II (CaMKII), known to enhance plasticity. Eulaminate areas have more elaborate laminar architecture than limbic areas and showed the opposite trend: they were enriched in markers of stability and had lower expression of the plasticity-related marker CaMKII. The expression of glial fibrillary acidic protein (GFAP), a marker of activated astrocytes, was also higher in limbic areas, suggesting that cellular stress correlates with the rate of circuit reshaping. Elevated markers of plasticity may endow limbic areas with flexibility necessary for learning and memory within an affective context, but may also render them vulnerable to abnormal structural changes, as seen in neurologic and psychiatric diseases.en_US
dc.description.sponsorshipThis work was supported by the National Institutes of Health (National Institute of Neurological Disorders and Stroke, grant number R01NS024760; National Institute of Mental Health, grant numbers R01MH057414 and R01MH101209); and by the Center of Excellence for Learning in Education, Science and Technology (CELEST), a National Science Foundation Science of Learning Center (grant number NSF SBE-0354378). M. A. Garcia-Cabezas was the recipient of a 2014 NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (grant number 22777, P&S Fund Investigator). (R01NS024760 - National Institutes of Health (National Institute of Neurological Disorders and Stroke); R01MH057414 - National Institute of Mental Health; R01MH101209 - National Institute of Mental Health; NSF SBE-0354378 - Center of Excellence for Learning in Education, Science and Technology (CELEST), a National Science Foundation Science of Learning Center; 22777 - NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation)en_US
dc.format.extent2392 - 2405 (14)en_US
dc.languageEnglish
dc.language.isoen_US
dc.publisherWILEYen_US
dc.relation.ispartofEUROPEAN JOURNAL OF NEUROSCIENCE
dc.subjectPlasticityen_US
dc.subjectSelective vulnerabilityen_US
dc.subjectLimbicen_US
dc.subjectEulaminateen_US
dc.subjectMacaque monkeyen_US
dc.titleMirror trends of plasticity and stability indicators in primate prefrontal cortexen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1111/ejn.13706
pubs.elements-sourceweb-of-scienceen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent Collegeen_US
pubs.organisational-groupBoston University, College of Health & Rehabilitation Sciences: Sargent College, Health Sciencesen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv282916


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