Show simple item record

dc.contributor.authorWerner, Jörg G.en_US
dc.contributor.authorLee, Hyominen_US
dc.contributor.authorWiesner, Ulrichen_US
dc.contributor.authorWeitz, David A.en_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2021-11-29T19:57:35Z
dc.date.issued2021-02-23
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/33556234
dc.identifier.citationJ.G. Werner, H. Lee, U. Wiesner, D.A. Weitz. 2021. "Ordered Mesoporous Microcapsules from Double Emulsion Confined Block Copolymer Self-Assembly.." ACS Nano, Volume 15, Issue 2, pp. 3490 - 3499. https://doi.org/10.1021/acsnano.1c00068
dc.identifier.issn1936-086X
dc.identifier.urihttps://hdl.handle.net/2144/43418
dc.description.abstractPolymeric microcapsules with shells containing homogeneous pores with uniform diameter on the nanometer scale are reported. The mesoporous microcapsules are obtained from confined self-assembly of amphiphilic block copolymers with a selective porogen in the shell of water-in-oil-in-water double emulsion drops. The use of double emulsion drops as a liquid template enables the formation of homogeneous capsules of 100s of microns in diameter, with aqueous cores encapsulated in a shell membrane with a tunable thickness of 100s of nanometers to 10s of microns. Microcapsules with shells that exhibit an ordered gyroidal morphology and three-dimensionally connected mesopores are obtained from the triblock terpolymer poly(isoprene)-block-poly(styrene)-block-poly(4-vinylpyridine) coassembled with pentadecylphenol as a porogen. The bicontinuous shell morphology yields nanoporous paths connecting the inside to the outside of the microcapsule after porogen removal; by contrast, one-dimensional hexagonally packed cylindrical pores, obtained from a traditional diblock copolymer system with parallel alignment to the surface, would block transport through the shell. To enable the mesoporous microcapsules to withstand harsh conditions, such as exposure to organic solvents, without rupture of the shell, we develop a cross-linking method of the nanostructured triblock terpolymer shell after its self-assembly. The microcapsules exhibit pH-responsive permeability to polymeric solutes, demonstrating their potential as a filtration medium for actively tunable macromolecular separation and purification. Furthermore, we report a tunable dual-phase separation method to fabricate microcapsules with hierarchically porous shells that exhibit ordered mesoporous membrane walls within sponge-like micron-sized macropores to further control shell permeability.en_US
dc.format.extent3490 - 3499en_US
dc.languageeng
dc.language.isoen_US
dc.relation.ispartofACS Nano
dc.subjectMicrofluidicsen_US
dc.subjectGyroiden_US
dc.subjectPeriodic nanostructureen_US
dc.subjectNanoporosityen_US
dc.subjectMacromolecular permeabilityen_US
dc.titleOrdered mesoporous microcapsules from double emulsion confined block copolymer self-assemblyen_US
dc.typeArticleen_US
dc.description.versionAccepted manuscripten_US
dc.identifier.doi10.1021/acsnano.1c00068
dc.description.embargo2022-02-23
pubs.elements-sourcepubmeden_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Mechanical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv601391


This item appears in the following Collection(s)

Show simple item record