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dc.contributor.advisorTrinkaus-Randall, Vickeryen_US
dc.contributor.authorSakowitz, Sara R.en_US
dc.date.accessioned2022-01-04T14:30:48Z
dc.date.available2022-01-04T14:30:48Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/2144/43540
dc.description.abstractThe gram-negative, gamma proteobacterium Pseudomonas aeruginosa demonstrates substantial metabolic flexibility, allowing it to survive and thrive in diverse environments. Indeed, its ability to carefully maintain a buffered intracellular oxidoreduction state permits it to maintain structural and functional stability in the face of both nutrient-poor and nutrient-rich conditions. It is clear that metabolism is simply central to the existence of this microbe, yet knowledge of the genetics and biochemistry underlying this deeply intricate world of metabolic regulation is fundamentally incomplete. Two critical metabolites, alpha-ketoglutarate and glutamine, appear at the intersection of carbon and nitrogen metabolism, and may represent the status of Pseudomonas’ intracellular carbon or nitrogen pools. However, the coordination of carbon and nitrogen assimilation, whether through PII proteins, the Ntr regulatory cascade, the CbrAB regulatory system, or the PTS-NTR system, as well as these pathways’ cross-talk and ability to control downstream processes based on nutrient availability, still remain to be elucidated. Further, a more comprehensive understanding of P. aeruginosa’s metabolic regulation could be significant for the development of new therapies that specifically target critical biochemical pathways involved in the metabolism of this organism and offer new hope to patients suffering from P. aeruginosa infections in the clinic. Thus, this review considers how, when, and why carbon and nitrogen metabolism may be regulated in Pseudomonas aeruginosa, and proposes there may be more interaction and cross-regulation between these two seemingly divergent metabolic arms than originally thought.en_US
dc.language.isoen_US
dc.subjectMicrobiologyen_US
dc.subjectAlpha-ketoglutarateen_US
dc.subjectCarbonen_US
dc.subjectGlutamineen_US
dc.subjectMetabolismen_US
dc.subjectNitrogenen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleCarbon/nitrogen sensing and downstream metabolic regulation in Pseudomonas aeruginosaen_US
dc.typeThesis/Dissertationen_US
dc.date.updated2021-12-11T02:04:08Z
etd.degree.nameMaster of Scienceen_US
etd.degree.levelmastersen_US
etd.degree.disciplineMedical Sciencesen_US
etd.degree.grantorBoston Universityen_US


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