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dc.contributor.authorZhang, Yanhangen_US
dc.contributor.authorYu, Xunjieen_US
dc.contributor.authorSuki, Belaen_US
dc.date.accessioned2022-01-14T16:34:51Z
dc.date.available2022-01-14T16:34:51Z
dc.date.issued2020-05-22
dc.date.issued2020
dc.identifier.citationY. Zhang, X. Yu, B. Suki. 2020. "Avalanches and Power Law Behavior in Aortic Dissection Progression." Science Advances, Volume 6, Issue 21, https://doi.org/10.1126/sciadv.aaz1173
dc.identifier.urihttps://hdl.handle.net/2144/43609
dc.description.abstractAortic dissection is a devastating cardiovascular disease known for its rapid propagation and high morbidity and mortality. The mechanisms underlying the propagation of aortic dissection are not well understood. Our study reports the discovery of avalanche-like failure of the aorta during dissection propagation that results from the local buildup of strain energy followed by a cascade failure of inhomogeneously distributed interlamellar collagen fibers. An innovative computational model was developed that successfully describes the failure mechanics of dissection propagation. Our study provides the first quantitative agreement between experiment and model prediction of the dissection propagation within the complex extracellular matrix (ECM). Our results may lead to the possibility of predicting such catastrophic events based on microscopic features of the ECM.en_US
dc.language.isoen_US
dc.relation.ispartofScience Advances
dc.rightsCopyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAvalanches and power law behavior in aortic dissection progressionen_US
dc.typeArticleen_US
dc.description.versionPublished versionen_US
dc.identifier.doi10.1126/sciadv.aaz1173
pubs.elements-sourcemanual-entryen_US
pubs.organisational-groupBoston Universityen_US
pubs.organisational-groupBoston University, College of Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Biomedical Engineeringen_US
pubs.organisational-groupBoston University, College of Engineering, Department of Mechanical Engineeringen_US
pubs.publication-statusPublisheden_US
dc.identifier.mycv547289


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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Except where otherwise noted, this item's license is described as Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).