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URI: http://hdl.handle.net/2144/938

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  • Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Zamboni, Robert J.; Kodukula, Krishna; Chen, Xiaohong (Mary Ann Liebert, Inc., 2020)
    In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ...
  • Epigenetic treatment of dermatologic disorders 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. (Wiley, 2019-09)
    Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ...
  • Robust visualization and discrimination of nanoparticles by interferometric imaging 

    Trueb, Jacob; Avci, Oguzhan; Sevenler, Derin; Connor, John H.; Ünlü, M. Selim (2017-03)
    Single-molecule and single-nanoparticle biosensors are a growing frontier in diagnostics. Digital biosensors are those which enumerate all specifically immobilized biomolecules or biological nanoparticles, and thereby ...
  • Enhanced light microscopy visualization of virus particles from Zika virus to filamentous ebolaviruses 

    Daaboul, George G.; Freedman, David S.; Scherr, Steven M.; Carter, Erik; Rosca, Alexandru; Bernstein, David; Mire, Chad E.; Agans, Krystle N.; Hoenen, Thomas; Geisbert, Thomas W.; Unlu, M. Selim; Connor, John H. (PUBLIC LIBRARY SCIENCE, 2017-06-26)
    Light microscopy is a powerful tool in the detection and analysis of parasites, fungi, and prokaryotes, but has been challenging to use for the detection of individual virus particles. Unlabeled virus particles are too ...
  • A new approach to treating neurodegenerative otologic disorders 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Irwin, Michael H.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna (2018)
    Hearing loss, the most common neurological disorder and the fourth leading cause of years lived with disability, can have profound effects on quality of life. The impact of this "invisible disability," with significant ...
  • Epigenetic treatment of neurodegenerative ophthalmic disorders: an eye toward the future. 

    Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Irwin, Michael H.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna (2017)
    Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all ...
  • Microbiota and neurological disorders: a gut feeling. 

    Moos, Walter H.; Faller, Douglas V.; Harpp, David N.; Kanara, Iphigenia; Pernokas, Julie; Powers, Whitney R.; Steliou, Kosta (2016)
    In the past century, noncommunicable diseases have surpassed infectious diseases as the principal cause of sickness and death, worldwide. Trillions of commensal microbes live in and on our body, and constitute the human ...
  • Gut microbiota and salivary diagnostics: the mouth is salivating to tell us something. 

    Kodukula, Krishna; Faller, Douglas V.; Harpp, David N.; Kanara, Iphigenia; Pernokas, Julie; Pernokas, Mark; Powers, Whitney R.; Soukos, Nikolaos S.; Steliou, Kosta; Moos, Walter H. (2017)
    The microbiome of the human body represents a symbiosis of microbial networks spanning multiple organ systems. Bacteria predominantly represent the diversity of human microbiota, but not to be forgotten are fungi, viruses, ...
  • Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction 

    Steliou, Kosta (Mesford Publisher Inc, 2019-03-13)
    Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as ...
  • Automated identification of neurons and their locations 

    Inglis, Andrew; Cruz, Luis; Roe, Dan L.; Stanley, Harry Eugene; Rosene, Douglas L.; Urbanc, Brigita (WILEY-BLACKWELL, 2008-06-01)
    Individual locations of many neuronal cell bodies (>10^4) are needed to enable statistically significant measurements of spatial organization within the brain such as nearest‐neighbour and microcolumnarity measurements. ...

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