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  • A Computational Approach for Deciphering the Organization of Glycosaminoglycans 

    Spencer, Jean L.; Bernanke, Joel A.; Buczek-Thomas, Jo Ann; Nugent, Matthew A. (Public Library of Science, 2010-2-23)
    BACKGROUND. Increasing evidence has revealed important roles for complex glycans as mediators of normal and pathological processes. Glycosaminoglycans are a class of glycans that bind and regulate the function of a wide ...
  • The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia 

    Grenz, Almut; Osswald, Hartmut; Eckle, Tobias; Yang, Dan; Zhang, Hua; Tran, Zung Vu; Klingel, Karin; Ravid, Katya; Eltzschig, Holger K. (Public Library of Science, 2008-6-24)
    BACKGROUND. Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified ...
  • Distamycin A Inhibits HMGA1-Binding to the P-Selectin Promoter and Attenuates Lung and Liver Inflammation during Murine Endotoxemia 

    Baron, Rebecca M.; Lopez-Guzman, Silvia; Riascos, Dario F.; Macias, Alvaro A.; Layne, Matthew D.; Cheng, Guiying; Harris, Cailin; Chung, Su Wol; Reeves, Raymond; von Andrian, Ulrich H.; Perrella, Mark A. (Public Library of Science, 2010-5-14)
    BACKGROUND. The architectural transcription factor High Mobility Group-A1 (HMGA1) binds to the minor groove of AT-rich DNA and forms transcription factor complexes ("enhanceosomes") that upregulate expression of select ...
  • Tar DNA binding Protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue 

    Liu-Yesucevitz, Liqun; Bilgutay, Aylin; Zhang, Yong-Jie; Vanderwyde, Tara; Citro, Allison; Mehta, Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert; Sherman, Michael; Petrucelli, Leonard; Wolozin, Benjamin (Public Library of Science, 2010-10-11)
    Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, ...
  • Loss of AND-34/BCAR3 Expression in Mice Results in Rupture of the Adult Lens 

    Near, Richard I.; Smith, Richard S.; Toselli, Paul A.; Freddo, Thomas F.; Bloom, Alexander B.; Vanden Borre, Pierre; Seldin, David C.; Lerner, Adam (Molecular Vision, 2009-4-03)
    PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor ...
  • A p130Cas Tyrosine Phosphorylated Substrate Domain Decoy Disrupts v-Crk Signaling 

    Kirsch, Kathrin H; Kensinger, Margaret; Hanafusa, Hidesaburo; August, Avery (BioMed Central, 2002-7-15)
    BACKGROUND. The adaptor protein p130Cas (Cas) has been shown to be involved in different cellular processes including cell adhesion, migration and transformation. This protein has a substrate domain with up to 15 tyrosines ...
  • Cytokine Reduction in the Treatment of Joint Conditions 

    Sipe, J. D.; Martel-Pelletier, J.; Otterness, I. G.; Pelletier, J.-P. (Hindawi Publishing Corporation, 1994)
    The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions ...
  • MURC/Cavin-4 and Cavin Family Members Form Tissue-Specific Caveolar Complexes 

    Bastiani, Michele; Liu, Libin; Hill, Michelle M.; Jedrychowski, Mark P.; Nixon, Susan J.; Lo, Harriet P.; Abankwa, Daniel; Luetterforst, Robert; Fernandez-Rojo, Manuel; Breen, Michael R.; Gygi, Steven P.; Vinten, Jorgen; Walser, Piers J.; North, Kathryn N.; Hancock, John F.; Pilch, Paul F.; Parton, Robert G. (The Rockefeller University Press, 2009-06-22)
    Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now ...
  • Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat 

    Kim, Noel N.; Stankovic, Miljan; Armagan, Abdullah; Cushman, Tulay T.; Goldstein, Irwin; Traish, Abdulmaged M. (BioMed Central, 2006-9-13)
    BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ...
  • Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers 

    Kim, Noel N.; Stankovic, Miljan; Cushman, Tulay T.; Goldstein, Irwin; Munarriz, Ricardo; Traish, Abdulmaged M. (BioMed Central, 2006-5-30)
    BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...

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