Blood Cell Factors and Tumor Growth in the Cheek Pouch of the Golden Hamster (Mesocricetus Auratus)
Sherman, Joseph Donald
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The formed elements of the hamster's blood were studied in relation to the growth of a one hundred per cent transplantable methylcholanthrene-induced hamster sarcoma in the cheek pouch of the hamster. An accurate tumor-growth curve and all of the observed phases of the tumor-growth process were related to the formed blood cell elements for a fifty-day period after tumor transplantation. The following hematological factors were studied in forty male and forty female hamsters, eight to ten weeks old during the tumor-growth process: Neutrophils, lymphocytes, monocytes, eosinophils, platelets, sedimentation rates, total white blood cells, total red blood cells, hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin concentration values. The averages of these factors were determined in each case for forty normal hamsters of both sexes, eight to ten weeks old. The normal averages reported did not differ significantly from the corresponding values previously reported by other investigators. Sedimentation rates were also determined for both experimental and control groups.[TRUNCATED]
Thesis (Ph.D.)--Boston University
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