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  • Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model 

    Tagge, Chad A.; Fisher, Andrew M.; Minaeva, Olga V.; Gaudreau-Balderrama, Amanda; Moncaster, Juliet A.; Zhang, Xiao-Lei; Wojnarowicz, Mark W.; Casey, Noel; Lu, Haiyan; Kokiko-Cochran, Olga N.; Saman, Sudad; Ericsson, Maria; Onos, Kristen D.; Veksler, Ronel; Senatorov, Vladimir V.; Kondo, Asami; Zhou, Xiao Z.; Miry, Omid; Vose, Linnea R.; Gopaul, Katisha R.; Upreti, Chirag; Nowinski, Christopher J.; Cantu, Robert C.; Alvarez, Victor E.; Hildebrandt, Audrey M.; Franz, Erich S.; Konrad, Janusz; Hamilton, James A.; Hua, Ning; Tripodis, Yorghos; Anderson, Andrew T.; Howell, Gareth R.; Kaufer, Daniela; Hall, Garth F.; Lu, Kun P.; Ransohoff, Richard M.; Cleveland, Robin O.; Kowall, Neil W; Stein, Thor D.; Lamb, Bruce T.; Huber, Bertrand R.; Moss, William C.; Friedman, Alon; Stanton, Patric K.; McKee, Ann C.; Goldstein, Lee E (OXFORD UNIV PRESS, 2018-02-01)
    The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic encephalopathy, and the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes ...
  • Inhibition of Dynamin-Dependent Endocytosis Increases Shedding of the Amyloid Precursor Protein Ectodomain and Reduces Generation Of Amyloid β Protein 

    Carey, Robyn M.; Balcz, Brigitte A.; Lopez-Coviella, Ignacio; Slack, Barbara E. (BioMed Central, 2005-8-11)
    BACKGROUND. The amyloid precursor protein (APP) is transported via the secretory pathway to the cell surface, where it may be cleaved within its ectodomain by α-secretase, or internalized within clathrin-coated vesicles. ...
  • Loss of AND-34/BCAR3 Expression in Mice Results in Rupture of the Adult Lens 

    Near, Richard I.; Smith, Richard S.; Toselli, Paul A.; Freddo, Thomas F.; Bloom, Alexander B.; Vanden Borre, Pierre; Seldin, David C.; Lerner, Adam (Molecular Vision, 2009-4-03)
    PURPOSE. AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor ...
  • Comparison of Proteomic and Transcriptomic Profiles in the Bronchial Airway Epithelium of Current and Never Smokers 

    Steiling, Katrina; Kadar, Aran Y.; Bergerat, Agnes; Flanigon, James; Sridhar, Sriram; Shah, Vishal; Ahmad, Q. Rushdy; Brody, Jerome S.; Lenburg, Marc E.; Steffen, Martin; Spira, Avrum (Public Libary of Science, 2009-4-9)
    BACKGROUND. Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the lung and airway, the impact of smoking on the airway epithelial proteome and its relationship to smoking-related ...
  • Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease 

    Kao, Patricia F.; Davis, David A.; Banigan, Meredith G.; Vanderburg, Charles R.; Seshadri, Sudha; Delalle, Ivana (Public Library of Science, 2010-10-13)
    During the progression of Alzheimer's disease (AD), hippocampal neurons undergo cytoskeletal reorganization, resulting in degenerative as well as regenerative changes. As neurofibrillary tangles form and dystrophic neurites ...
  • Epigenetic Differences in Cortical Neurons from a Pair of Monozygotic Twins Discordant for Alzheimer's Disease 

    Mastroeni, Diego; McKee, Ann; Grover, Andrew; Rogers, Joseph; Coleman, Paul D. (Public Library of Science, 2009-8-12)
    DNA methylation [1], [2] is capable of modulating coordinate expression of large numbers of genes across many different pathways, and may therefore warrant investigation for their potential role between genes and disease ...
  • Microarray Gene Expression Profiling and Analysis in Renal Cell Carcinoma 

    Liou, Louis S.; Shi, Ting; Duan, Zhong-Hui; Sadhukhan, Provash; Der, Sandy D.; Novick, Andrew A.; Hissong, John; Skacel, Marek; Almasan, Alexandru; DiDonato, Joseph A. (BioMed Central, 2004-6-22)
    BACKGROUND. Renal cell carcinoma (RCC) is the most common cancer in adult kidney. The accuracy of current diagnosis and prognosis of the disease and the effectiveness of the treatment for the disease are limited by the ...
  • Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma 

    Liu, Huiqing; Brannon, Angela R.; Reddy, Anupama R.; Alexe, Gabriela; Seiler, Michael W.; Arreola, Alexandra; Oza, Jay H.; Yao, Ming; Juan, David; Liou, Louis S.; Ganesan, Shridar; Levine, Arnold J.; Rathmell, W. K.; Bhanot, Gyan V. (BioMed Central, 2010-4-27)
    BACKGROUND. MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription. Putative mRNA targets of microRNA identified from seed ...
  • Allergens Induce Enhanced Bronchoconstriction and Leukotriene Production in C5 Deficient Mice 

    McKinley, Laura; Kim, Jiyoun; Bolgos, Gerald L.; Siddiqui, Javed; Remick, Daniel G. (BioMed Central, 2006-10-17)
    BACKGROUND. Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 ...
  • The Expression Level of HJURP Has an Independent Prognostic Impact and Predicts the Sensitivity to Radiotherapy in Breast Cancer 

    Hu, Zhi; Huang, Ge; Sadanandam, Anguraj; Gu, Shenda; Lenburg, Marc E.; Pai, Melody; Bayani, Nora; Blakely, Eleanor A.; Gray, Joe W; Mao, Jian-Hua (BioMed Central, 2010-3-8)
    INTRODUCTION. HJURP (Holliday Junction Recognition Protein) is a newly discovered gene reported to function at centromeres and to interact with CENPA. However its role in tumor development remains largely unknown. The goal ...

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