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  • Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides 

    Coleman, Christina; Levine, Danielle; Kishore, Raj; Qin, Gangjian; Thorne, Tina; Lambers, Erin; Sasi, Sharath P.; Yaar, Mina; Gilchrest, Barbara A.; Goukassian, David A. (Hindawi Publishing Corporation, 2010-6-28)
    Telomere homolog oligonucleotides (T-oligos) activate an innate telomere-based program that leads to multiple anticancer effects. T-oligos act at telomeres to initiate signaling through the Werner protein and ATM kinase. ...
  • Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters 

    Boyd, Ashleigh S.; Wood, Kathryn J. (Public Library of Science, 2010-6-4)
    BACKGROUND. The fully differentiated progeny of ES cells (ESC) may eventually be used for cell replacement therapy (CRT). However, elements of the innate immune system may contribute to damage or destruction of these tissues ...
  • Role of BMP-4 and Its Signaling Pathways in Cultured Human Melanocytes 

    Park, Hee-Young; Wu, Christina; Yaar, Mina; Stachur, Christina M.; Kosmadaki, Marita; Gilchrest, Barbara A. (Hindawi Publishing Corporation, 2009-12-30)
    Bone Morphogenetic Protein (BMP-4) was shown to down-regulate melanogenesis, in part, by decreasing the level of tyrosinase [Yaar et al. (2006) JBC:281]. Results presented here show that BMP-4 down-regulated the protein ...
  • Nonlinear Modeling of Venous Leg Ulcer Healing Rates 

    Cardinal, Matthew; Phillips, Tania; Eisenbud, David E.; Harding, Keith; Mansbridge, Jonathan; Armstrong, David G. (BioMed Central, 2009-3-31)
    BACKGROUND. The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics. METHODS. We studied 3,588 serial wound tracings of 338 venous ...
  • Telomeric DNA Induces Apoptosis and Senescence of Human Breast Carcinoma Cells 

    Yaar, Mina; Eller, Mark S.; Panova, Izabela; Kubera, John; Wee, Lee Hng; Cowan, Kenneth H.; Gilchrest, Barbara A. (BioMed Central, 2007-1-26)
    INTRODUCTION. Cancer is a leading cause of death in Americans. We have identified an inducible cancer avoidance mechanism in cells that reduces mutation rate, reduces and delays carcinogenesis after carcinogen exposure, ...
  • Preventive Strategies and Research for Ultraviolet-Associated Cancer 

    Koh, H K (National Institute of Environmental Health Sciences, 1995-11)
    Ultraviolet (UV)-associated cancer is the most common cancer in the United States. Approximately 90% of nonmelanoma skin cancer and 65% of melanoma are attributable to UV exposure and theoretically could be eliminated by ...
  • Can an Hour or Two of Sun Protection Education Keep the Sunburn Away? Evaluation of the Environmental Protection Agency's Sunwise School Program 

    Geller, Alan C; Rutsch, Linda; Kenausis, Kristin; Selzer, Paula; Zhang, Zi (BioMed Central, 2003-11-3)
    BACKGROUND: Melanoma incidence is rising at a rate faster than any other preventable cancer in the United States. Childhood exposure to ultraviolet (UV) light increases risk for skin cancer as an adult, thus starting ...