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  • A transitional opioid program to engage hospitalized drug users 

    Shanahan, C. W.; Beers, D.; Alford, D. P.; Brigandi, E.; Samet, J. H. (J Gen Intern Med., 2010-08)
    BACKGROUND: Many opioid-dependent patients do not receive care for addiction issues when hospitalized for other medical problems. Based on 3 years of clinical practice, we report the Transitional Opioid Program (TOP) ...
  • Noninvasive Assessment of Antenatal Hydronephrosis in Mice Reveals a Critical Role for Robo2 in Maintaining Anti-Reflux Mechanism 

    Wang, Hang; Li, Qinggang; Liu, Juan; Mendelsohn, Cathy; Salant, David J.; Lu, Weining (PLoS ONE, 2011-09-20)
    Antenatal hydronephrosis and vesicoureteral reflux (VUR) are common renal tract birth defects. We recently showed that disruption of the Robo2 gene is associated with VUR in humans and antenatal hydronephrosis in knockout ...
  • Inhibitory Effects of Robo2 on Nephrin: A Crosstalk between Positive and Negative Signals Regulating Podocyte Structure 

    Fan, Xueping; Li, Qinggang; Pisarek-Horowitz, Anna; Rasouly, Hila Milo; Wang, Xiangling; Bonegio, Ramon G.; Wang, Hang; McLaughlin, Margaret; Mangos, Steve; Kalluri, Raghu; Holzman, Lawrence B.; Drummond, Iain A.; Brown, Dennis; Salant, David J.; Lu, Weining (Elsevier, 2012-07-26)
    Robo2 is the cell surface receptor for the repulsive guidance cue Slit and is involved in axon guidance and neuronal migration. Nephrin is a podocyte slit- diaphragm protein that functions in the kidney glomerular filtration ...
  • NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium 

    Heard-Costa, Nancy L.; Zillikens, M. Carola; Monda, Keri L.; Johansson, Åsa; Harris, Tamara B.; Fu, Mao; Haritunians, Talin; Feitosa, Mary F.; Aspelund, Thor; Eiriksdottir, Gudny; Garcia, Melissa; Launer, Lenore J.; Smith, Albert V.; Mitchell, Braxton D.; McArdle, Patrick F.; Shuldiner, Alan R.; Bielinski, Suzette J.; Boerwinkle, Eric; Brancati, Fred; Demerath, Ellen W.; Pankow, James S.; Arnold, Alice M.; Chen, Yii-Der Ida; Glazer, Nicole L.; McKnight, Barbara; Psaty, Bruce M.; Rotter, Jerome I.; Amin, Najaf; Campbell, Harry; Gyllensten, Ulf; Pattaro, Cristian; Pramstaller, Peter P.; Rudan, Igor; Struchalin, Maksim; Vitart, Veronique; Gao, Xiaoyi; Kraja, Aldi; Province, Michael A.; Zhang, Qunyuan; Atwood, Larry D.; Dupuis, Josée; Hirschhorn, Joel N.; Jaquish, Cashell E.; O'Donnell, Christopher J.; Vasan, Ramachandran S.; White, Charles C.; Aulchenko, Yurii S.; Estrada, Karol; Hofman, Albert; Rivadeneira, Fernando; Uitterlinden, André G.; Witteman, Jacqueline C. M.; Oostra, Ben A.; Kaplan, Robert C.; Gudnason, Vilmundur; O'Connell, Jeffrey R.; Borecki, Ingrid B.; Van Duijn, Cornelia M.; Cupples, L. Adrienne; Fox, Caroline S.; North, Kari E. (Public Library of Science, 2009-6-26)
    Central abdominal fat is a strong risk factor for diabetes and cardiovascular disease. To identify common variants influencing central abdominal fat, we conducted a two-stage genome-wide association analysis for waist ...
  • Annual Ambient Black Carbon Associated with Shorter Telomeres in Elderly Men: Veterans Affairs Normative Aging Study 

    McCracken, John; Baccarelli, Andrea; Hoxha, Mirjam; Dioni, Laura; Melly, Steve; Coull, Brent; Suh, Helen; Vokonas, Pantel; Schwartz, Joel (National Institute of Environmental Health Sciences, 2010-11)
    BACKGROUND. Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. OBJECTIVE. ...
  • Low-Level Lead Exposure, Metabolic Syndrome, and Heart Rate Variability: The VA Normative Aging Study 

    Park, Sung Kyun; Schwartz, Joel; Weisskopf, Marc; Sparrow, David; Vokonas, Pantel S.; Wright, Robert O.; Coull, Brent; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2006-11)
    BACKGROUND. Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure. OBJECTIVE. We examined the association of low-level lead ...
  • Modifying Effects of the HFE Polymorphisms on the Association between Lead Burden and Cognitive Decline 

    Wang, Florence T.; Hu, Howard; Schwartz, Joel; Weuve, Jennifer; Spiro, Avron S.; Sparrow, David; Nie, Huiling; Silverman, Edwin K.; Weiss, Scott T.; Wright, Robert O. (National Institute of Environmental Health Sciences, 2007-08)
    BACKGROUND. As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. OBJECTIVE. ...
  • Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort 

    Chahine, Teresa; Baccarelli, Andrea; Litonjua, Augusto; Wright, Robert O.; Suh, Helen; Gold, Diane R.; Sparrow, David; Vokonas, Pantel; Schwartz, Joel (National Institute of Environmental Health Sciences, 2007-11)
    BACKGROUND AND OBJECTIVES. We have previously shown that reduced defenses against oxidative stress due to glutathione S-transferase M1 (GSTM1) deletion modify the effects of PM2.5 (fine-particulate air pollution of < 2.5 ...
  • Effects of Air Pollution on Heart Rate Variability: The VA Normative Aging Study 

    Park, Sung Kyun; O'Neill, Marie S.; Vokonas, Pantel S.; Sparrow, David; Schwartz, Joel (National Institue of Environmental Health Sciences, 2005-03)
    Reduced heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with air pollution, especially fine particulate matter [< 2.5 μm in aerodynamic diameter (PM2.5)]. We examined the ...
  • Stress as a Potential Modifier of the Impact of Lead Levels on Blood Pressure: The Normative Aging Study 

    Peters, Junenette L.; Kubzansky, Laura; McNeely, Eileen; Schwartz, Joel; Spiro, Avron; Sparrow, David; Wright, Robert O.; Nie, Huiling; Hu, Howard (National Institute of Environmental Health Sciences, 2007-08)
    BACKGROUND. Lead exposure and psychological stress have been independently associated with hypertension in various populations, and animal studies suggest that when they co-occur, their effects may be exacerbated. OBJECTIVES. ...

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