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URI: http://hdl.handle.net/2144/974

Biomedical engineering is advancing rapidly and producing important innovations that improve our quality of life. From understanding the human genome to pioneering surgical tools, Boston University biomedical engineers are committed the advancement of research and education in biotechnology, biomolecular engineering, sensory systems, cardiopulmonary engineering, neuroscience, micro-and nano-systems and biomechanics and biomaterials.

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Biomedical Engineering
John A. White, Ph.D., Chairman
44 Cummington St., Room 403
Phone: (617) 353-2805
Fax: (617) 353-6766

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  • More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction 

    Li, Baoqiang; Esipova, Tatiana V.; Sencan, Ikbal; Kılıç, Kıvılcım; Fu, Buyin; Desjardins, Michele; Moeini, Mohammad; Kura, Sreekanth; Yaseen, Mohammad A.; Lesage, Frederic; Østergaard, Leif; Devor, Anna; Boas, David A.; Vinogradov, Sergei A.; Sakadžić, Sava (2019-07-15)
    Our understanding of how capillary blood flow and oxygen distribute across cortical layers to meet the local metabolic demand is incomplete. We addressed this question by using two-photon imaging of resting-state microvascular ...
  • Model-based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach 

    Rasmussen, Peter M.; Smith, Amy F.; Sakadžić, Sava; Boas, David A.; Pries, Axel R.; Secomb, Timothy W.; Østergaard, Leif (2017-05)
    OBJECTIVE: In vivo imaging of the microcirculation and network-oriented modeling have emerged as powerful means of studying microvascular function and understanding its physiological significance. Network-oriented modeling ...
  • Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21 

    Magnain, Caroline; Augustinack, Jean C.; Tirrell, Lee; Fogarty, Morgan; Frosch, Matthew P.; Boas, David; Fischl, Bruce; Rockland, Kathleen S. (Springer Science and Business Media LLC, 2019-01)
    Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence ...
  • Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1 

    Trilles, Richard; Beglov, Dmitri; Chen, Qiujia; He, Hongzhen; Wireman, Randall; Reed, April; Chennamadhavuni, Spandan; Panek, James S.; Brown, Lauren E.; Vajda, Sandor; Porco, John A.; Kelley, Mark R.; Georgiadis, Millie M. (AMER CHEMICAL SOC, 2019-02-28)
    Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and ...
  • Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy 

    Belghasem, Mostafa E.; A'amar, Ousama; Roth, Daniel; Walker, Joshua; Arinze, Nkiruka; Richards, Sean M.; Francis, Jean M.; Salant, David J.; Chitalia, Vipul C.; Bigio, Irving J. (2019-05-09)
    The universal pathologic features implicated in the progression of chronic kidney disease (CKD) are interstitial fibrosis and tubular atrophy (IFTA). Current methods of estimating IFTA are slow, labor-intensive and fraught ...
  • COMBREX: a project to accelerate the functional annotation of prokaryotic genomes 

    Roberts, Richard J.; Chang, Yi-Chien; Hu, Zhenjun; Rachlin, John N.; Anton, Brian P.; Pokrzywa, Revonda M.; Choi, Han-Pil; Faller, Lina L.; Guleria, Jyotsna; Housman, Genevieve; Klitgord, Niels; Mazumdar, Varun; McGettrick, Mark G.; Osmani, Lais; Swaminathan, Rajeswari; Tao, Kevin R.; Letovsky, Stan; Vitkup, Dennis; Segre, Daniel; Salzberg, Steven L.; Delisi, Charles; Steffen, Martin; Kasif, Simon (OXFORD UNIV PRESS, 2011-01-01)
    COMBREX (http://combrex.bu.edu) is a project to increase the speed of the functional annotation of new bacterial and archaeal genomes. It consists of a database of functional predictions produced by computational biologists ...
  • Surface modification of stainless steel for biomedical applications: revisiting a century-old material 

    Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S.; Kanayeva, Damira (Elsevier BV, 2018-12)
    Stainless steel (SS) has been widely used as a material for fabricating cardiovascular stents/valves, orthopedic prosthesis, and other devices and implants used in biomedicine due to its malleability and resistance to ...
  • Automatic cell segmentation by adaptive thresholding (ACSAT) for large-scale calcium imaging datasets 

    Shen, Simon P.; Tseng, Hua-An; Hansen, Kyle R.; Wu, Ruofan; Gritton, Howard J.; Si, Jennie; Han, Xue (2018-09)
    Advances in calcium imaging have made it possible to record from an increasingly larger number of neurons simultaneously. Neuroscientists can now routinely image hundreds to thousands of individual neurons. An emerging ...
  • Video-rate volumetric neuronal imaging using 3D targeted illumination 

    Xiao, Sheng; Tseng, Hua-an; Gritton, Howard; Han, Xue; Mertz, Jerome (NATURE PUBLISHING GROUP, 2018-05-21)
    Fast volumetric microscopy is required to monitor large-scale neural ensembles with high spatio-temporal resolution. Widefield fluorescence microscopy can image large 2D fields of view at high resolution and speed while ...
  • Cross-modal cue effects in motion processing 

    Hanada, G. M.; Ahveninen, J.; Calabro, F. J.; Yengo-Kahn, A.; Vaina, Lucia M. (Brill Academic Publishers, 2018)
    The everyday environment brings to our sensory systems competing inputs from different modalities. The ability to filter these multisensory inputs in order to identify and efficiently utilize useful spatial cues is necessary ...

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