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URI: http://hdl.handle.net/2144/987

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  • A modeling study of the responses of the lateral superior olive to ipsilateral sinusoidally amplitude-modulated tones 

    Wang, Le; Colburn, H. Steven (2012-04)
    The lateral superior olive (LSO) is a brainstem nucleus that is classically understood to encode binaural information in high-frequency sounds. Previous studies have shown that LSO cells are sensitive to envelope interaural ...
  • Inhibition shapes response selectivity in the inferior colliculus by gain modulation 

    Wang, Le; Gittelman, Joshua X.; Colburn, H. S.; Pollak, George D. (2012)
    Pharmacological block of inhibition is often used to determine if inhibition contributes to spike selectivity, in which a preferred stimulus evokes more spikes than a null stimulus. When inhibitory block reduces spike ...
  • A binaural grouping model for predicting speech intelligibility in multitalker environments 

    Colburn, H. Steven; Mi, Jing
    Spatially separating speech maskers from target speech often leads to a large intelligibility improvement. Modeling this phenomenon has long been of interest to binaural-hearing researchers for uncovering brain mechanisms ...
  • Neuronal imaging with ultrahigh dynamic range multiphoton microscopy 

    Yang, Ruohui; Weber, Timothy D.; Witkowski, Ellen D.; Davison, Ian G.; Mertz, Jerome (2017-07-19)
    Multiphoton microscopes are hampered by limited dynamic range, preventing weak sample features from being detected in the presence of strong features, or preventing the capture of unpredictable bursts in sample strength. ...
  • Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits 

    Kondabolu, Krishnakanth; Roberts, Erik A.; Bucklin, Mark; McCarthy, Michelle M.; Kopell, Nancy; Han, Xue (2016-05-31)
    Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease ...
  • How proteins bind macrocycles 

    Villar, Elizabeth A.; Beglov, Dmitri; Chennamadhavuni, Spandan; Porco, John A.; Kozakov, Dima; Vajda, Sandor; Whitty, Adrian (2014-09)
    The potential utility of synthetic macrocycles (MCs) as drugs, particularly against low-druggability targets such as protein-protein interactions, has been widely discussed. There is little information, however, to guide ...
  • Function-driven, graphical design tool for microfluidic chips: 3DuF 

    Lippai, Joshua; Sanka, Radhakrishna; Lashkaripour, Ali; Densmore, Douglas (International Workshop on Bio-Design Automation (IWBDA), 2017-08)
    The use of microfluidic chips for applications in biology to reduce the cost, time, and difficulty of automating experiments, while promising, has proven to have barriers to entry. In particular, the cost of the equipment ...
  • mLSI design with MINT 

    Sanka, Radhakrishna; Densmore, Douglas; Lippai, Joshua (IWBDA, 2017-08)
    Fluigi is a microfluidic design framework that allows researchers to realize abstract descriptions of liquid flow relationships automatically as physical devices and corresponding control software. Its goal is to provide ...
  • MINT - Microfluidic Netlist 

    Sanka, Radhakrishna; Huang, Haiyao; Silva, Ryan; Densmore, Douglas (IWBDA, 2016-03)
    Fluigi is a microfluidic design framework that allows researchers to realize abstract descriptions of liquid flow relationships automatically as physical devices and corresponding control software. Its goal is to provide ...
  • Fluigi Cloud - A cloud CAD platform for microfluidics 

    Sanka, Radhakrishna; Subacius, Kestutis; Kapadia, Priya; Densmore, Douglas; McCormack, Shane; Asthana, Anish (IWBDA, 2017-08)
    With microfluidic large scale integration and the emergence of many new synthetic biology technologies, there is an ever increasing benefit in using computer automated design (CAD) tools for scaling designs to larger and ...

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