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    • ENG: Mechanical Engineering: Scholarly Papers
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    •   OpenBU
    • College of Engineering
    • Mechanical Engineering
    • ENG: Mechanical Engineering: Scholarly Papers
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    Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature

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    1-2.pdf (1.363Mb)  Supplementary Data
    Date Issued
    2006-09-01
    Author
    Hazony, Yehonathan
    Lu, Jun
    Hilaire, Cynthia St.
    Ravid, Katya
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    Permanent Link
    10.1093/nar/gkl578
    https://hdl.handle.net/2144/997
    Citation
    2006. "Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature," Nucleic Acids Research. vol. 34 issue. 16 .
    Abstract
    Identification of common sub-sequences for a group of functionally related DNA sequences can shed light on the role of such elements in cell-specific gene expression. In the megakaryocytic lineage, no one single unique transcription factor was described as linage specific, raising the possibility that a cluster of gene promoter sequences presents a unique signature. Here, the megakaryocytic gene promoter group, which consists of both human and mouse 5' non-coding regions, served as a case study. A methodology for group-combinatorial search has been implemented as a customized software platform. It extracts the longest common sequences for a group of related DNA sequences and allows for single gaps of varying length, as well as double- and multiple-gap sequences. The results point to common DNA sequences in a group of genes that is selectively expressed in megakaryocytes, and which does not appear in a large group of control, random and specific sequences. This suggests a role for a combination of these sequences in cell-specific gene expression in the megakaryocytic lineage. The data also point to an intrinsic cross-species difference in the organization of 5' non-coding sequences within the mammalian genomes. This methodology may be used for the identification of regulatory sequences in other lineages.
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