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dc.contributor.authorHazony, Yehonathanen_US
dc.contributor.authorLu, Junen_US
dc.contributor.authorHilaire, Cynthia St.en_US
dc.contributor.authorRavid, Katyaen_US
dc.date.accessioned2009-04-13T23:06:22Z
dc.date.available2009-04-13T23:06:22Z
dc.date.issued2006-09-01
dc.identifier.citation2006. "Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature," Nucleic Acids Research. vol. 34 issue. 16 .
dc.identifier.otherPMC1636359
dc.identifier.uri10.1093/nar/gkl578
dc.identifier.urihttps://hdl.handle.net/2144/997
dc.description.abstractIdentification of common sub-sequences for a group of functionally related DNA sequences can shed light on the role of such elements in cell-specific gene expression. In the megakaryocytic lineage, no one single unique transcription factor was described as linage specific, raising the possibility that a cluster of gene promoter sequences presents a unique signature. Here, the megakaryocytic gene promoter group, which consists of both human and mouse 5' non-coding regions, served as a case study. A methodology for group-combinatorial search has been implemented as a customized software platform. It extracts the longest common sequences for a group of related DNA sequences and allows for single gaps of varying length, as well as double- and multiple-gap sequences. The results point to common DNA sequences in a group of genes that is selectively expressed in megakaryocytes, and which does not appear in a large group of control, random and specific sequences. This suggests a role for a combination of these sequences in cell-specific gene expression in the megakaryocytic lineage. The data also point to an intrinsic cross-species difference in the organization of 5' non-coding sequences within the mammalian genomes. This methodology may be used for the identification of regulatory sequences in other lineages.en_US
dc.relation.ispartofNucleic Acids Research
dc.relation.ispartofseriesvol. 34 issue. 16
dc.titleHematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signatureen_US
dc.typeArticleen_US


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