Predicting substance use disorder using long-term ADHD medication records in Truven
Files
Published version
Date
2019-05-19
Authors
Fouladvand, Sajjad
Hankosky, Emily R.
Henderson, Darren W.
Bush, Heather M.
Chen, Jin
Dwoskin, Linda P.
Freeman, Patricia R.
Kantak, Kathleen M.
Talbert, Jeffery, C.
Tao, Shiqiang
Version
Published version
Embargo Date
2020-09-17
OA Version
Citation
S. Fouladvand, E.R. Hankosky, D. Henderson, H.M. Bush, J. Chen, L.P. Dwoskin, P.R. Freeman, K.M. Kantak, J.C. Talbert, S. Tao, G.Q. Zhang. 2019. "Predicting Substance Use Disorder using Long-term ADHD Medication Records in Truven." Health Informatics Journal,
Abstract
About 20% of individuals with attention deficit hyperactivity disorder are first diagnosed during adolescence.
While preclinical experiments suggest that adolescent-onset exposure to attention deficit hyperactivity disorder medication is an important factor in the development of substance use disorder phenotypes in adulthood, the long-term impact of attention deficit hyperactivity disorder medication initiated during adolescence has been largely unexplored in humans. Our analysis of 11,624 adolescent enrollees with attention deficit hyperactivity disorder in the Truven database indicates that temporal medication features, rather than stationary features, are the most important factors on the health consequences related to substance use disorder and attention deficit hyperactivity disorder medication initiation during adolescence.
Description
License
Attribution-NonCommercial 4.0 International