Gingival fluid fucose to protein ratios as indicators of severity of periodontal disease
Date
1980
DOI
Authors
Novaes, Arthur B.
Version
OA Version
Citation
Abstract
In a previous study, protein concentrations were determined from gingival fluid samples that were collected from two separate groups of subjects (clinically normal and severe clinical inflammation). Since our findings were not statistically significant, it was decided to investigate other aspects of the protein molecule, not only to get a better understanding of the pathogenesis of periodontal disease, but to try to develop chemical indices for evaluating the severity of periodontal inflammation.
Gingival fluid samples were collected from two equal groups of eight subjects, a clinically normal group and a severe clinical inflammation group. Two sets of gingival fluid samples and 5 cc of blood was collected from each subject. Total protein and fucose concentrations were determined colorimetrically from the gingival fluid and plasma samples.
A significantly higher total protein concentration was found for the control (clinically normal) group when compared to the experimental (severe clinical inflammation) group. This isprobably due to the higher gingival fluid flow rate found in the experimental group. The total fucose analyses showed no statistical difference between both groups, but when fucose to protein ratios were studied, a significantly higher ratio was found for the experimental group when compared to the controls. This probably represents the breakdown of plasma and tissue glycoproteins which may occur as a result of inflammation.
Description
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Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1980 (Specialty)
Bibliography: leaves 75-88.
Thesis (M.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1980 (Specialty)
Bibliography: leaves 75-88.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.