Cyclic adenosine 3',5'-monophosphate and cyclic quanosine 3',5'-monophosphate in the human dental pulp and their relationship to inflammation
Date
1978
DOI
Authors
Sproles, Alan Carl
Version
OA Version
Citation
Abstract
Cyclic AMP and cyclic GMP have been suggested as regulators and mediators of in vivo inflammatory and immunological responses. The purpose of this study was to determine the presence or absence of these cyclic nucleotides and to investigate their possible relationship to pulpal inflammation. In addition, this study has attempted to provide support for the hypothesis that these cyclic nucleotides are ultimately involved in the symptoms that we see in pulpitis. Correlations of other known inflammatory mediators such as prostaglandins, histamine, endotoxins, and B-glucuronidase have been made to the cyclic nucleotides. This study provides evidence for the presence of cyclic adenosine 3’,5’ - monophosphate and cyclic guanosine 3', 5’ -monophosphate in human dental pulps.
Samples were collected from fifty patients requiring endodontic therapy or those requiring extractions for orthodontic reasons. The samples were divided into two groups, normal and pulpitis, according to clinical signs and symptoms. Correlations were made to age and sex data.
[TRUNCATED]
Description
PLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please click Download and log in with a valid BU account to access. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.
Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1978 (Endodontics)
Bibliography: leaves 99-111.
Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1978 (Endodontics)
Bibliography: leaves 99-111.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.