Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders
Date
2016-04-01
Authors
Brozovich, F. V.
Nicholson, C. J.
Degen, C. V.
Gao, Yuan Z.
Aggarwal, M.
Morgan, K. G.
Version
Accepted manuscript
OA Version
Citation
FV Brozovich, CJ Nicholson, CV Degen, Yuan Z Gao, M Aggarwal, KG Morgan. 2016. "Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders." PHARMACOLOGICAL REVIEWS, Volume 68, Issue 2, pp. 476 - 532 (57). https://doi.org/10.1124/pr.115.010652
Abstract
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.
Description
License
Attribution 4.0 International