Evolution of residual solid stresses and viscoelastic properties in murine brains by age
Embargo Date
2025-01-15
OA Version
Citation
Abstract
Residual solid stresses are mechanical forces generated and transmitted by solid components of tissue. Here, we quantified the residual solid stress developed in the brain and kidney by tissue slicing. By this method, we showed that murine brains contain higher residual solid stresses than murine kidneys, which were previously shown to have negligible residual solid stress. Since development and aging differentially affects residual solid stress in each organ, we utilize the slicing method to quantify the evolution of residual solid stresses in brains from mice which are 5–7 days old to 22 months old. We found that residual solid stresses increase rapidly in the early stages of tissue growth and development. We also evaluated the changes of viscoelastic properties in the murine brain with age to analyze the relationship between viscoelastic properties and residual solid stress changes, and their potential connection with tissue development. Additionally, we tested the whole brain from adult mice with a slicing method to evaluate the distribution of residual solid stress.