Regulation of lysyl oxidase isoforms by TNF-a in vascular smooth muscle cell and tissues; and biological activity of the lysyl oxidase propeptide in vascular smooth muscle cells
Date
2008
DOI
Authors
Garzon, Paola Andrea Hurtado
Version
OA Version
Citation
Abstract
Lysyl oxidase (LOX) is the enzyme that catalyzes the formation of aldehydes from
lysine residues in collagen and elastin resulting in cross-linking. LOX plays a very
important role in extracellular matrix deposition and maturation. In the context of
cardiovascular disease, it has been stated that LOX is up-regulated in fibrotic diseases
suggesting that LOX regulation could contribute to cardiovascular diseases. TNF-a is a
major pro-inflammatory cytokine that controls some of the pathologies associated
with the development of atherosclerosis following vascular injury, however, little is
known about the effect of this cytokine on the regulation of lysyl oxidase in
cardiovascular tissues. [TRUNCATED]
Description
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Dental Medicine, 2008 (Dept. of Periodontology and Oral Biology).
Includes bibliographical references: leaves 130-153.
Includes bibliographical references: leaves 130-153.
License
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