Mini-review: Ergothioneine and ovothiol biosyntheses, an unprecedented trans-sulfur strategy in natural product biosynthesis
Files
Accepted manuscript
Date
2018-06-19
Authors
Naowarojna, Nathchar
Cheng, Ronghai
Chen, Li
Quill, Melissa
Xu, Meiling
Zhao, Changming
Liu, Pinghua
Version
Accepted manuscript
OA Version
Citation
Nathchar Naowarojna, Ronghai Cheng, Li Chen, Melissa Quill, Meiling Xu, Changming Zhao, Pinghua Liu. 2018. "Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis.." Biochemistry, Volume 57, Issue 24, pp. 3309 - 3325. https://doi.org/10.1021/acs.biochem.8b00239
Abstract
As one of the most abundant elements on earth, sulfur is part of many small molecular metabolites and is key to their biological activities. Over the past few decades, some general strategies have been discovered for the incorporation of sulfur into natural products. In this review, we summarize recent efforts in elucidating the biosynthetic details for two sulfur-containing metabolites, ergothioneine and ovothiol. Their biosyntheses involve an unprecedented trans-sulfur strategy, a combination of a mononuclear non-heme iron enzyme-catalyzed oxidative C-S bond formation reaction and a PLP enzyme-mediated C-S lyase reaction.