A comparative study of ascorbic acid deficiency and excessive thyroid function in the guinea pig
Date
1967
DOI
Authors
Binderman, Arnold F.
Version
OA Version
Citation
Abstract
Medical and Dental Literature, is replete with documentation of similarities in an organism’s response to a variety of endogenous and exogenous stimulants. Material, apparently unrelated in chemical or physical properties of their own, may effect one phase of a physiological function upon which another is dependent. Hence, the absence of the latter function appears as a result of the inhibition of the former.
Thus when Goldman described the dental and periodontal effects of hyperthyroidism in the guinea pig, he noted effects which bore a striking resemblance to those accompanying C-avitaminosis. With later work modifying the effects of altered thyroid function by means of high doses of ascorbic acid, a relationship between these two substances has been established, a relationship which gives insight into many other organic metabolic interactions and interdependencies.
The objective of this study is to determine whether an interrelationship exists between ascorbic acid deficiency and varying degrees of increased thyroid activity, and will be based on the effects of both materials on collagen metabolism in wound healing and on alterations observed in the dental structure, in deficiency and supplementation.
Description
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Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1967 (Periodontology)
Includes bibliography.
Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1967 (Periodontology)
Includes bibliography.
License
This work is protected by copyright. Downloading is restricted to the BU community. If you are the author of this work and would like to make it publicly available, please contact open-help@bu.edu.